Results 71 to 80 of about 12,219 (259)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Towards Circularity: A Qualitative Study of Circularity Adoption in Australian Architectural Practice

Architecture
This qualitative research investigates the adoption of Circular Economy (CE) principles in contemporary Australian architectural practice, referred to as circularity, to address climate change, resource scarcity, and increasing demands for built ...
Christopher Bamborough, Matthias Hank Haeusler, Michael J. Ostwald, Mohsen Kafaei, Yousef A. Y. Thaher, Daniel Oteng, Jane Burry, Mark Burry, Tim Schork   +8 more
doaj   +1 more source

BIM2BEM integrated approach: Examining status of the adoption of building information modelling and building energy models in Egyptian architectural firms

Ain Shams Engineering Journal, 2018
Egyptian architectural firms are moving from the use of CAD towards the adoption of BIM. Meanwhile, these firms are challenged with the use of BEM in order to cope with the call for energy conservation.
Laila Mohamed Khodeir, Ashraf Ali Nessim
doaj   +1 more source

Improving mental health and wellbeing in elderly people isolated at home due to architectural barriers: A community health intervention. [PDF]

Aten Primaria, 2021
Daban F, Garcia-Subirats I, Porthé V, López M, de-Eyto B, Pasarín MI, Borrell C, Artazcoz L, Pérez A, Díez E.   +9 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Research on Pathology Information Management of Educational Architectural Heritage Based on Digital Technology: The Case of James Jackson Gymnasium

Buildings
Rapid advances in technology have led to an increasing demand for this type of information in the field of cultural heritage and architectural conservation.
Hechi Wang, Xinyi He, Zhaoyi Yan, Siyu Lei, Shengzhong Luo, Jingjing Lei, Qi Zhou   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Bridging policy gaps and institutional barriers in Nigeria's architectural registration

City, Territory and Architecture
Architectural Registration in Nigeria has faced considerable challenges over the past eight years (2015–2023), impacting the profession's growth. This study identifies areas for improvement and offers recommendations to strengthen the registration ...
Ebere Donatus Okonta, Rose Chigozie Njoku, Chinedu Uchechukwu Oluigbo, Macaulay Atahchegbe Egwuma   +3 more
doaj   +1 more source