Results 71 to 80 of about 12,079 (259)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

BIM2BEM integrated approach: Examining status of the adoption of building information modelling and building energy models in Egyptian architectural firms

Ain Shams Engineering Journal, 2018
Egyptian architectural firms are moving from the use of CAD towards the adoption of BIM. Meanwhile, these firms are challenged with the use of BEM in order to cope with the call for energy conservation.
Laila Mohamed Khodeir, Ashraf Ali Nessim
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Towards Circularity: A Qualitative Study of Circularity Adoption in Australian Architectural Practice

Architecture
This qualitative research investigates the adoption of Circular Economy (CE) principles in contemporary Australian architectural practice, referred to as circularity, to address climate change, resource scarcity, and increasing demands for built ...
Christopher Bamborough, Matthias Hank Haeusler, Michael J. Ostwald, Mohsen Kafaei, Yousef A. Y. Thaher, Daniel Oteng, Jane Burry, Mark Burry, Tim Schork   +8 more
doaj   +1 more source

Improving mental health and wellbeing in elderly people isolated at home due to architectural barriers: A community health intervention. [PDF]

Aten Primaria, 2021
Daban F, Garcia-Subirats I, Porthé V, López M, de-Eyto B, Pasarín MI, Borrell C, Artazcoz L, Pérez A, Díez E.   +9 more
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Research on Pathology Information Management of Educational Architectural Heritage Based on Digital Technology: The Case of James Jackson Gymnasium

Buildings
Rapid advances in technology have led to an increasing demand for this type of information in the field of cultural heritage and architectural conservation.
Hechi Wang, Xinyi He, Zhaoyi Yan, Siyu Lei, Shengzhong Luo, Jingjing Lei, Qi Zhou   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Bridging policy gaps and institutional barriers in Nigeria's architectural registration

City, Territory and Architecture
Architectural Registration in Nigeria has faced considerable challenges over the past eight years (2015–2023), impacting the profession's growth. This study identifies areas for improvement and offers recommendations to strengthen the registration ...
Ebere Donatus Okonta, Rose Chigozie Njoku, Chinedu Uchechukwu Oluigbo, Macaulay Atahchegbe Egwuma   +3 more
doaj   +1 more source