Results 51 to 60 of about 1,606,724 (205)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

The Technology Architectural Record [PDF]

open access: yes, 1907
Publication of the Massachusetts Institute of Technology Architectural Society. Volume 1.
Massachusetts Institute of Technology. Department of Architecture   +1 more
core  

Call for Contributions: International Conference on Architectural Criticism, "On the Duty and Power of Architectural Criticism"

open access: yes, 2021
Hélène Jannière and Paolo Scrivano, scientific coordinators of Mapping Architectural Criticism, are very pleased to announce the forthcoming International Conference on Architectural Criticism, On the Duty and Power of Architectural Criticism.
Mapping Architectural Criticism
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Understanding the Spatial Needs of Transgender Individuals

open access: yesEnquiry: The ARCC Journal of Architectural Research
This study investigates the spatial requirements of transgender individuals in urban and sacred contexts, with particular reference to pilgrimage sites in Saundatti.
Sheetal Lad, Kavita Murugkar
doaj   +3 more sources

Constrains and barriers of implementing sustainability into architectural professional practice in Jordan

open access: yesAlexandria Engineering Journal, 2019
Sustainable buildings created a challenge for architectural professional practice in Jordan, and no doubt that there are many obstacles to the widespread of implementing sustainable building practices.
Hikmat H. Ali, Ayat A. Alkayed
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Actors and Vehicles of Architectural Criticism (1)

open access: yes, 2016
Actors of Criticism: How the Editors of AD Magazine shaped Architecture Stephen Parnell Newcastle University From its establishment in 1930, architect John Kendall briefly edited Architectural Design (AD) magazine until his death in 1934 when Frederic ...
Mapping Architectural Criticism
core   +1 more source

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