Results 31 to 40 of about 1,606,724 (205)

A Study of Architectural Barriers and the Potential Role of Assistive Technologies in Long-term Healthcare Centres for People with Alzheimer’s

open access: yesInteraction Design and Architecture(s), 2022
Alzheimer's disease (AD) changes a person's relationship with space. While research exists on how an interactive therapeutic environment can enhance the quality of life for people with Alzheimer's disease (PWAD), PWADs as end-users are not ...
Heidi Elnimr
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

TODAY'S CITIES: CHALLENGES FOR REHABILITATION NURSES FOR INCLUSION

open access: yesRevista Portuguesa de Enfermagem de Reabilitação, 2020
The architectural barriers on public highway cause inaccessibility, contributing to the limitation of functionality and creation of disability. Objectives: to analyze the conditions of accessibility on public highways in view of the needs of disabled ...
Ana Isabel Ribeiro Da Silva Pereira   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

News : Colloquium, 13 - 14 september 2022 : Architectural criticism, Medias and Memory

open access: yes, 2022
ARCHITECTURAL CRITICISM, MEDIAS AND MEMORY is a colloquium to be held on 13‒14 September 2022 at the office of the Council of Architecture and Urbanism, Rio de Janeiro session (CAU-RJ).
Mapping Architectural Criticism
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Preserving the Past, Embracing the Future: Co-Design Strategies for Achieving Harmony Between Heritage Sites and Accessibility Needs

open access: yesHeritage
Canada’s heritage sites, while fewer in number compared to Europe, face significant challenges in accessibility due to strict preservation laws. Many were built before social inclusion became a priority, making them difficult to navigate for individuals ...
Maryem Lakoud   +6 more
doaj   +1 more source

The changing patterns of architectural design education [PDF]

open access: yes, 2008
Digital technologies have been introduced to students of architecture for over two decades and at present it could be argued that students are producing some of the highest quality designs, and some of the most interesting forms ever to come from ...
Horne, Margaret, Giddings, Bob
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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