Results 41 to 50 of about 15,745 (300)

TODAY'S CITIES: CHALLENGES FOR REHABILITATION NURSES FOR INCLUSION

Revista Portuguesa de Enfermagem de Reabilitação, 2020
The architectural barriers on public highway cause inaccessibility, contributing to the limitation of functionality and creation of disability. Objectives: to analyze the conditions of accessibility on public highways in view of the needs of disabled ...
Ana Isabel Ribeiro Da Silva Pereira, Maria Manuela Ferreira Pereira Da Silva Martins, Rute Salomé da Silva Pereira, Bárbara Pereira Gomes, João Santos, Paulo Alexandre Matos Cunha   +5 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Preserving the Past, Embracing the Future: Co-Design Strategies for Achieving Harmony Between Heritage Sites and Accessibility Needs

Heritage
Canada’s heritage sites, while fewer in number compared to Europe, face significant challenges in accessibility due to strict preservation laws. Many were built before social inclusion became a priority, making them difficult to navigate for individuals ...
Maryem Lakoud, Ernesto Morales, Alicia Ruiz-Rodrigo, Isabelle Feillou, Samuel Mathieu, Jonathan Riendeau, François Routhier   +6 more
doaj   +1 more source

Key determinants and barriers to digital innovation adaptation among architectural practices [PDF]

, 2016
Digital innovation is recognized as a new architectural design process to improve building design, productivity with less construction cost and time.
Ramilo, Runddy Dacallos
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Supramolecular architecture of a multi-component biomimetic lipid barrier formulation

Journal of Colloid and Interface Science, 2021
Biomimetic liquid crystalline systems are widely used in skin care cosmetics and topical pharmaceutical preparations. Our ability to rationally design such formulations, however, is hampered by our incomplete understanding of their structure on the nanoscale.Using polarized light microscopy and small-angle and wide-angle X-ray scattering, the molecular
Delaram Ahmadi, Ruth Ledder, Najet Mahmoudi, Peixun Li, James Tellam, Douglas Robinson, Richard K. Heenan, Paul Smith, Christian D. Lorenz, David J. Barlow, M. Jayne Lawrence   +10 more
openaire   +6 more sources

A multivariate regression analysis of barriers to digital technologies adoption in the construction industry

, 2023
PurposeWith growing concern about sustainable development and increased awareness of environmental issues, digital technologies (DTs) are gaining prominence and becoming a promising trend to improve productivity, sustainability and project performance in
Pelosi, Antony, Alice Yan Chang-Richards, Chang-Richards, Alice Yan, Xichen Chen, Tak Wing Yiu, Florence Yean Yng Ling, Chen, Xichen, Yiu, Tak Wing, Nan Yang, Antony Pelosi, Ling, Florence Yean Yng, Yang, Nan   +11 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source