Results 41 to 50 of about 12,042 (261)

Preserving the Past, Embracing the Future: Co-Design Strategies for Achieving Harmony Between Heritage Sites and Accessibility Needs

Heritage
Canada’s heritage sites, while fewer in number compared to Europe, face significant challenges in accessibility due to strict preservation laws. Many were built before social inclusion became a priority, making them difficult to navigate for individuals ...
Maryem Lakoud, Ernesto Morales, Alicia Ruiz-Rodrigo, Isabelle Feillou, Samuel Mathieu, Jonathan Riendeau, François Routhier   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Supramolecular architecture of a multi-component biomimetic lipid barrier formulation

Journal of Colloid and Interface Science, 2021
Biomimetic liquid crystalline systems are widely used in skin care cosmetics and topical pharmaceutical preparations. Our ability to rationally design such formulations, however, is hampered by our incomplete understanding of their structure on the nanoscale.Using polarized light microscopy and small-angle and wide-angle X-ray scattering, the molecular
Delaram Ahmadi, Ruth Ledder, Najet Mahmoudi, Peixun Li, James Tellam, Douglas Robinson, Richard K. Heenan, Paul Smith, Christian D. Lorenz, David J. Barlow, M. Jayne Lawrence   +10 more
openaire   +6 more sources

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Barriers to BIM Adoption in Design Practice: A Systematic Review of Developing Countries

Nature: National Academic Journal of Architecture
Despite the progress made with BIM integration into the construction industries of many developed countries, its adoption remains limited in most developing countries.
Daniel Ebo Hagan, Tutin Aryanti, Ilhamdaniah Ilhamdaniah   +2 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Why Architectural History Struggles to Integrate with the Design Studio

Proceedings of the International Conference of Contemporary Affairs in Architecture and Urbanism-ICCAUA
The architectural design studio is located at the centre of the learning expected in the Bachelor of Architecture course. It is expected that all other subjects must inform and enrich the learning in the design studio.
Shalini Sheoran, Manoj Panwar
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source