Results 101 to 110 of about 436,555 (285)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Traditional City Pattern and Houses of Çanakkale-Bozcaada

Gazi Üniversitesi Fen Bilimleri Dergisi, 2017
Looking closely to Bozcaada architectural characteristics, it is possible to see Turkish and Rum influence. For instance, the houses in Alaybey neighborhood have the architectural characteristics of the former, while the ones in Cumhuriyet neighborhood ...
Abdurrahman Sedat SAYGI, Sare SAHİL
doaj  

Characteristics of technological componentin architectural composition

Вестник гражданских инженеров, 2020
As a result of this research, there has been established a possibility of presenting the multifaceted property of technological effectiveness as a component of spatial composition of architectural image. The author specifies the main features of the multifaceted property of architectural image technological effectiveness.
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The architectural characteristics of the hamstring muscles do not differ between male and female elite-level rugby union players. [PDF]

Front Physiol, 2023
Cronin K, Foley S, Cournane S, De Vito G, Kerin F, Farrell G, Delahunt E.   +6 more
europepmc   +1 more source

Analytical and Comparative Study of Change in Functional Purpose of Some Archaeological and Historical Architectures in Cairo During the 19th and 20th Centuries [PDF]

, 2019
This research paper aims to discuss the nature of change in the functional purpose of some archaeological and historical buildings in Cairo during the 19th and 20th centuries along with a comparative study of some of the most important heritage ...
Khalifa, G. D. (Ghadeer)
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The appearance of new architectural representation in Korean modern architecture in the late 19th and early 20th centuries

Journal of Asian Architecture and Building Engineering
This study explores the characteristics of architectural representation in Korean modern architecture during the transition to modernity. For this purpose, this research examines the appearance of new architectural representation in Korean modern ...
Myengsoo Seo
doaj   +1 more source

Response Mechanisms of Adventitious Root Architectural Characteristics of Nitraria tangutorum Shrubs to Soil Nutrients in Nabkha. [PDF]

Plants (Basel), 2022
Li X, Dang X, Gao Y, Meng Z, Chen X, Wang Y.   +5 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source