Results 31 to 40 of about 63,712 (264)

Exploration of street space architectural color measurement based on street view big data and deep learning-A case study of Jiefang North Road Street in Tianjin.

open access: yesPLoS ONE, 2023
Urban space architectural color is the first feature to be perceived in a complex vision beyond shape, texture and material, and plays an important role in the expression of urban territory, humanity and style. However, because of the difficulty of color
Xin Han   +15 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Margi Park concept design: Nursing home for seniors and EU-standards [PDF]

open access: yesFacta Universitatis. Series: Architecture and Civil Engineering, 2010
The physical environment has a great potential for supporting resident's residual way-finding abilities. Until now little systematic research has been carried out to identify supportive architectural characteristics. The architectural structure of the
Dietrich Wolfgang Christ   +1 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Research on Digital Modeling and Life Cycle Information Management of Architectural Heritage Protection Based on BIM

open access: yesARCHive-SR, 2021
Building information modelling (BIM) has been adopted in the architectural heritage industry. The digital protection method with BIM Technology as the core can introduce the information management workflow into the protection of architectural heritage ...
Zhao Liang
doaj   +1 more source

Potential of unconventional design methods for expanding compositional solutions for architectural character of buildings [PDF]

open access: yesE3S Web of Conferences, 2020
The present paper considers the capabilities of advanced methods for design of architectural objects. The paper gives characteristics of the process of composing as the traditional and most common method for designing architectural structures.
Pleshivtsev Aleksandr
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Influence of architectural heritage on the identity and present-day value of American-designed universities’ campuses in Asia

open access: yesBuilt Heritage, 2020
In this study, through case studies of campus architectural heritage, the preservation of architectural heritage on campuses is explored. In addition, the effects of architectural heritage preservation on the identity of campuses are investigated, and ...
Yan Hong
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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