Results 41 to 50 of about 1,729 (289)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

COPYRIGHT FOR THE PROJECT IN ARCHITECTURAL COMPETITIONS

Ukrainian Journal of Civil Engineering and Architecture, 2021
Постановка проблеми. Архітектурне проєктування, в процесі якого створюються об’єкти авторського права, є одією з ключових індустрій, на якій базуються економіки країн сучасного світу. Значення архітектурної діяльності для гармонійного розвитку суспільства беззаперечне, як із точки зору розроблення проєктів та створення споруд, культурна цінність яких ...
V. Babenko, K. Davydenko
openaire   +4 more sources

The prequalified competition - how are architects appointed to invited architectural competitions?

Enquiry: The ARCC Journal of Architectural Research, 2012
This article presents results from a study of prequalification in architectural competitions. The aim is to develop knowledge of how the organizer appoints candidates to invited competitions.
Magnus Rönn
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

An entrepreneurial countryside?

Cidades, Comunidades e Território, 2021
Architecture and urban design are central selling points in globalized models of urban development, advocated by city strategies to boost competitiveness.
Heini-Emilia Saari
doaj  

Creating the Belgrade waterfront identity through a prism of architecture and urban planning competitions [PDF]

Spatium, 2017
The architecture and urban planning competitions are a form of architectural activity that bring creative ideas important for parts of cities or territories, and they can precede the creation of future planning documentation.
Petrović-Balubdžić Miroslava
doaj   +1 more source

Loci of competition for future internet architectures [PDF]

IEEE Communications Magazine, 2011
Designing for competition is an important consideration for the design of future Internet architectures. Network architects should systematically consider the loci of competition in any proposed network architecture. To be economically sustainable, network architectures should encourage competition within each locus, anticipate and manage the ...
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source