Results 101 to 110 of about 13,395,687 (337)

Clayville Rural Life Center and Museum - Publications Series II - Research Report #05: Inns and Taverns in the Midwest - Typical Functions, Forms, and Layouts [PDF]

open access: yes, 1981
Part I of this report explores the functions of typical inns and taverns. It established the bases for setting up a typical inventory of furniture, cookware, eating utensils, and all the other likely necessary and not-so-necessary items which would be ...
Hawes, Edward L., Kwedar, Melinda F.
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The initiation to architectural analysis viewed by a group of architect teachers [PDF]

open access: yes, 2014
Ponencia presentada a Session 4: Investigar los procesos de diseño: etnografías y análisis de dialogías sociales / Research through the design processes: etnographic and social dialogical perspectivesThis article is about a pedagogical experience in ...
Fakhfakh Ben Yaghlane, Mona   +1 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Selecting the best architectural form of the office building with the level of non-stop function against explosion

open access: yesEngineering Structures and Technologies, 2015
Regarding the importance of structures in sustainable development of countries, the necessity to consider them versus inflicted forces has an especial position. One of the inflicted forces upon these structures is explosion.
Jalal Nakhaei   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Research on Puxia Village of Traditional Settlement and Architectural Form [PDF]

open access: yes, 2016
中国传统聚落根植于几千年农耕文明,聚落形成是历史文化、生活习俗、伦理道德等多方面共同作用的结果,是适应自然环境生态的体现,更是劳动人民利用智慧创造美好舒适的乡村生活的表现。传统聚落形态各异、瑰丽多姿,是建筑遗产重要的组成部分,属于不可再生的宝贵财富。而目前,许多保留下来的珍贵古村落,也在面临着多种问题:无人问津,村落破败;新建建筑增多,改变传统聚落面貌;一些村落过渡的旅游开发......等等。本文从这一背景出发,基于对传统聚落保护与更新,通过分析聚落物质基础和文化特征 ...
王雅萍
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A web services architecture for learning object discovery and assembly [PDF]

open access: yes, 2004
Courseware systems are often based on an assembly of different components, addressing the different needs of storage and delivery functionality. The Learning Technology Standard Architecture LTSA provides a generic architectural framework for these ...
Barrett, Ronan, Pahl, Claus
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Penang/ Georgetown's Shophouse Facade And Visual Problems, Analytic Study [PDF]

open access: yes, 2016
The architectural form of Penang/Georgetown shophouses is now threatened by urban development, which involves many kinds of visual problems causes. The purpose of this study is to clarify these problems, review the visual properties of shophouse facade ...
Sabah, Omar Adil, Samad, Muna Hanim
core  

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