Results 121 to 130 of about 13,395,687 (337)
A Longitudinal Study of Identifying and Paying Down Architectural Debt
, 2018 Architectural debt is a form of technical debt that derives from the gap between the architectural design of the system as it "should be" compared to "as it is". We measured architecture debt in two ways: 1) in terms of system-wide coupling measures, and
Cai, Yuanfang +6 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Criteria for defining the architectural form of wooden structures
Selected Scientific Papers: Journal of Civil Engineering, 2015 Currently we can see many instances, both new and old, where the roof and roof structure dominates the design concept and becomes an important part of the internal space of a building.
Sečka Lukáš
doaj +1 more source
Architecture et forme urbaine [PDF]
Urban History Review, 1989 This article examines Montreal's urban fabric as it was shaped during the urban expansion at the end of the 19th century. Focusing on the development of the St. Jean-Baptiste neighbourhood between 1870 and 1914, the study attempts to explain the origins of the street layouts and the built forms of this area.
openaire +2 more sources
, 2009 My research has for many years been concerned with ceremonial objects, the spaces they occupy and other associated elements (music, ritual, contemplation).
Howard, Ashley
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Dialectics of Form and Functionin Architectural Aesthetics
Rivista di Estetica, 2015 It is through the dialectics of form and function in architecture, and in particular in the contradiction between the two, that the artistic and aesthetic dimensions of architecture can be developed: its expression of ideas, reflection of human identity,
John Hendrix
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Problem based learning in architectural education [PDF]
, 2007 There is limited published research and discussion on pedagogical approaches in architectural education. Problem (or Project) Based Learning is used successfully in other professional disciplines, and, consequently, there have been attempts to utilise ...
Bridges, Alan
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