Results 111 to 120 of about 340,000 (305)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Loess Strength Prediction Model Under Dry–Wet Cycles Based on the IAGA-BP Algorithm

Applied Sciences
In the long-term operation of canals in loess areas, instability and landslides frequently occur due to the effect of wetting–drying cycles, which severely restricts the long-term safe operation of engineering projects.
Cheng Luo, Haijuan Wang, Feng Guo, Xu Guo   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

K-means Clustering and Control Analysis of Main Tunneling Parameters of Mud-Water Balanced Shields in Water-Rich Round Gravel Strata

Zhongwai Gonglu
It is important to set reasonable tunneling parameters according to the ground conditions to reduce the deformation of existing tunnels, since the close crossing of new shield tunnels is likely to cause deformation in the adjacent existing tunnels. The K-
LYU Yiye, PEI Lihua, LIN Dong, YANG Xingyu, GUI Yue   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Investigating elective courses in architectural education

Frontiers of Architectural Research, 2018
One of the approaches used by educational institutions to ensure that their programs reflect advances and changes in the architectural profession is the inclusion of elective courses.
Mohammed Ghonim, Nehad Eweda
doaj   +1 more source

A new way of teaching different subjects in a foreign language in the Building Engineering Degree at the Universidad Politécnica. [PDF]

, 2011
The European Union has been promoting linguistic diversity for many years as one of its main educational goals. This is an element that facilitates student mobility and student exchanges between different universities and countries and enriches the ...
Casaravilla Gil, Ana, Gil López, Tomás, Río Merino, Mercedes del, Valiente López, Mercedes   +3 more
core   +1 more source

Associative Processor Architecture—a Survey [PDF]

ACM Computing Surveys, 1977
Stephen S. Yau, H. S. Fung
openaire   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Experiences in Photogrammetric and Laser Scanner Surveing of Architectural Heritage

Geoinformatics FCE CTU, 2011
The integration of different methodologies and simplification of procedures is surely one of the most important current themes in survey techniques for researching cultural heritage, especially for architectural heritage.  The traditional methods for the
Mauro Caprioli, Maurizio Minchilli, Alfredo Scognamiglio   +2 more
doaj   +1 more source