Results 51 to 60 of about 205,019 (293)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Een werkelijk monumentale gevel: De prijsvraag voor de uitbreiding van het hoofdkantoor van De Nederlandsche Bank aan de Oude Turfmarkt in Amsterdam (1915-1916)

open access: yesBulletin KNOB, 2015
In September 1915, De Nederlandsche Bank (DNB) held an invited design competition for a new building beside the bank’s existing headquarters on Oude Turfmarkt in Amsterdam.
Gert Eijkelboom
doaj   +1 more source

Ecological Architecture Design in Urban and Rural Planning Applied Statistical Design

open access: yesIOP Conference Series: Earth and Environmental Science, 2020
Abstract The regional characteristic of China becomes noticeable. Urban and rural planning must consider the factors of ecological environment. Ecological architecture design will become the main direction of urban and rural planning and development, but also meet the requirements of sustainable development in China. In recent years, the
Zhiqin Huang, Lipu Huang, Meiling Wang
openaire   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Determination and Evaluation of Field Adequacy by Ankara Göksu Park Users

open access: yesTurkish Journal of Agriculture: Food Science and Technology, 2022
It is one of the biggest city parks of Ankara, which people can easily reach in daily use, walking, jogging, sitting, picnicking, playing etc. Göksu Park, which provides opportunities for activities such as, is built on the old Susuz pond in Eryaman. The
Elif Nur Doğan, Sertaç Güngör
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Design methodology for a school prototype: Jean Prouvé’s Jules Ferry School Group in Dieulouard, France, 1952–1953 [PDF]

open access: yes, 2019
The catastrophic destruction of buildings in France during World War II demanded that reconstruction become one of the primary objectives in the immediate post-war period.
Bueno Pozo, Verónica   +1 more
core  

Le Nouveau Jardin Pittoresque: ethics, aesthetics and garden design in Belgium (1913-1940) [PDF]

open access: yes, 2012
Le Nouveau Jardin Pittoresque (The New Picturesque Garden) association was founded in 1913 to ‘renew and popularize garden art’ in Belgium. Originally, the emancipation of the lower classes was put forward as an important task; the association acted as a
Notteboom, Bruno
core   +1 more source

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