Results 131 to 140 of about 9,582,228 (342)
Families, insanity and the psychiatric institution in Australia and New Zealand, 1860-1914 [PDF]
, 2006 International historians have begun to challenge the view that the nineteenth-century psychiatric hospital was a place of horrors and custody, and have shown that families were sometimes intimate with the institutions of the past, often participating in ...
Coleborne, Catharine
core +1 more source
Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome
Advanced Science, EarlyView.Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel +19 more
wiley +1 more source
Methods and standards development for three-dimensional mapping of the Antioch Quadrangle, Lake County, Illinois a pilot study [PDF]
, 2005 The Pilot Study for the Central Great Lakes Geologic Mapping Coalition (CGLGMC) focused on the Antioch Quadrangle, Lake County, Illinois developing a series of maps and digital products, several protocols for database development and maintenance and ...
Barnhardt, Michael L., Berg, Richard C.
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Advanced Science, EarlyView.ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang +17 more
wiley +1 more source
Story of the 22nd Battalion, September 15th, 1916: The Capture of Courcelette [PDF]
, 2012 Editor’s note: The George Metcalf Archival Collection at the Canadian War Museum has a thick file of original materials related to the 22nd Battalion’s role in the battle of Courcelette including messages written by its commander, Lieutenant-Colonel T.L.
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Advanced Science, EarlyView.Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng +9 more
wiley +1 more source
Invest to Save: Report and Recommendations of the NSF-DELOS Working Group on Digital Archiving and Preservation [PDF]
, 2003 Digital archiving and preservation are important areas for research and development, but there is no agreed upon set of priorities or coherent plan for research in this area.
Ashley, K. +9 more
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Advanced Science, EarlyView.Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu +12 more
wiley +1 more source
METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation
Advanced Science, EarlyView.METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li +19 more
wiley +1 more source