Results 31 to 40 of about 1,282 (265)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Technical re-equipment of Soviet industry in the 1950^s

Гуманитарные и юридические исследования, 2023
Introduction. The need to ensure technological sovereignty, which is critically important in the complicated geopolitical situation, actualizes the study of the Soviet experience of industrial and scientific and technical policy.   Materials and Methods. 
E. V. Bodrova, V. V. Kalinov
doaj   +1 more source

The Cluj County and the Cluj Region Healthcare System During the First Years of Communism (1948-1952) [PDF]

Revista Română de Sociologie, 2010
The paper follows the internal evolution of the Cluj County (1948-1949) and of the Cluj Region (1949-1952) Healthcare System. It starts by presenting the reorganization of the sanitary circumscriptions and it continues by offering data on the ...
VLAD POPOVICI
doaj  

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

The 'Popolo'’s Room. Describing medieval archives through a fourteenth century Bologna’s inventory

Journal of Open Humanities Data
This article presents a dataset derived from a medieval archive inventory preserved in the State Archives of Bologna, the Liber seu memoriale of 1324. This source, resulting from the reorganization of an important portion of the archives of the ancient ...
Giuliano Milani, Armando Antonelli
doaj   +1 more source

ISSUES OF REORGANIZATION OF JUDICIAL PROCEEDINGS ON THE AGENDA OF CONGRESSES OF ENTRUSTED KABARDIANS AND BALKARS IN THE LAST THIRD OF THE XIX - EARLY XX СЕNTURY

Кавказология, 2019
Congress of entrusted – an original institution of district self-government of Kabardinians and Balkars, regularly functioning under the control of the Russian administration.
D. N. PRASOLOV
doaj   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Historicizing the Invisible: Cognition and Transformation in Thomas Kuhn

Religions
This article argues that Thomas Kuhn’s The Structure of Scientific Revolutions developed a historicized and developmental account of cognition in which scientific transformation depends on encounters with what is not yet discernible within existing ...
Mark Nader Basafa
doaj   +1 more source

ACADEMY OF SCIENCES IN THE CONDITIONS OF THE DECAY OF THE USSR

Российский технологический журнал, 2018
On the basis of unpublished archival materials, the problem of finding the optimal strategy for the further existence of the Academy of Sciences in the context of the struggle for power between the Union and Republican centers in the last years of the ...
E. V. Bodrova
doaj   +1 more source