Results 41 to 50 of about 283,865 (345)

“There is a history in all men’s lives”: a journey in transnational documentation

open access: yesLa Bretagne Linguistique
Although archives are understood as unique and undivided records accumulated throughout an individual or a collective's existence, archivists and researchers at large can be confronted by the dissemination in various institutions or countries of ...
Marie-Alice Le Corvec
doaj   +1 more source

Archival ethics: The truth of the matter [PDF]

open access: yes, 2008
This essay explores the question of whether records professionals are as aware of the ethical dimensions of their work as they should be. It consider first the historical and professional context of archival ethics, then examines a recent case about ...
Adkins   +51 more
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Základny archivního výzkumu

open access: yesAntropoWebzin, 2008
The article is an introduction to the topic of the archival science which is concentrated on practical use of archive. First part contains definitions of basic terms of archive and archival documents and informs about the system of archives in Czech ...
Jan Šimek
doaj  

Sociolinguistics II: Deviance, Dystopia, And Democracy (LING82) Syllabus [PDF]

open access: yes, 2018
This course builds upon foundational concepts in sociolinguistic theory to examine discourses of news and entertainment media, across science fiction and politics.
Thomas, Jamie A.
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

The archive beyond the archive

open access: yesBibliothecae.it, 2022
The publication of Federico Valacchi’s book, Gli archivi tra storia, uso e futuro: dentro la società (Milano, Editrice Bibliografica, 2021) it is an opportunity to reflect on the role of archives and archivists.
Mario Aldo Toscano
doaj   +1 more source

The Sciences of the Archive [PDF]

open access: yesOsiris, 2012
Since the mid-nineteenth century, classifications of knowledge have opposed the bookish, history-conscious humanities to the empirical, amnesiac sciences. Yet in the sciences of the archive, the library stands alongside the laboratory, the observatory, and the field as an important site of research.
openaire   +2 more sources

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