Results 81 to 90 of about 25,687,323 (301)

Modeling archival repositories for digital libraries [PDF]

open access: yes, 1999
This paper studies the archival problem: how a digital li-brary can preserve electronic documents over long periods of time. We analyze how an archival repository can fail and we present different strategies that help solve the problem.
Hector Garcia-molina, Arturo Crespo
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende   +26 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

Looking for What You Are Looking for

open access: yesVIEW Journal of European Television History and Culture, 2013
In this essay, the author reflects on her first search with the online search system of the Netherlands Institute for Sound and Vision.
Van Gorp, Jasmijn
doaj   +1 more source

An Analysis of Twitter and Facebook Use by the Archival Community [PDF]

open access: yes, 2010
This paper discusses how the archival community is using social networking services such as Twitter and Facebook as outreach tools. The study analyzes the usage patterns of 195 individual and institutional users over a thirty-two-day period during the ...
Crymble, Adam
core  

Collecting behavioural addiction treatment data using Freedom of Information requests [PDF]

open access: yes, 2014
There is now a growing movement that views a number of behaviours as potentially addictive including many that do not involve the ingestion of a drug (i.e., behavioural addictions such as gambling addiction and sex addiction).
Griffiths, M, Dhuffar, M
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza   +19 more
wiley   +1 more source

Using archival research in marketing [PDF]

open access: yes
Archival research is an under-rated and under-utilised research method that has much to offer. This chapter explores how and why to use archival data in research, as well as how to conduct archival research and analyse the findings.
Gill, D., Tomasella, B.
core  

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach   +23 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou   +16 more
wiley   +1 more source

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