Results 211 to 220 of about 2,313,292 (299)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

RCSB Protein Data Bank: Delivering integrative structures alongside experimental structures and computed structure models. [PDF]

Nucleic Acids Res
Vallat B, Rose Y, Piehl DW, Duarte JM, Bittrich S, Bi C, Segura J, Zalevsky A, Sekharan MR, Webb BM, Bhikadiya C, Voigt M, Henry J, Chao H, Pingale A, Raymond D, Sagendorf J, Peisach E, Feng Z, Guranovic V, Smith J, Rose AS, Young JY, Berman HM, Sali A, Burley SK.   +25 more
europepmc   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

Chromosome-level genome assembly of masu salmon (Oncorhynchus masou masou). [PDF]

Sci Data
Wu B, Yu Y, Zhang X, Chen H, Qin C, Xie J, Li L, Wu W, Chen J.   +8 more
europepmc   +1 more source

Internet Archive’s Trump Archive

Archivalia, 2017
openaire   +2 more sources

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Archives secrètes, archives publiques ?

, 2012
openaire   +2 more sources

Complete Genome Sequences of seven cluster DE1 phages isolated using <i>Gordonia terrae</i>. [PDF]

MicroPubl Biol
Almutairi A, Marsala G, Mershon N, Ball S.   +3 more
europepmc   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Draft genome sequence of the plastic-degrading fungus Fusicolla acetilerea strain NIBRFGC000505922. [PDF]

BMC Genom Data
Dalantai M, Lee SY, Jung HY, You YH, Kim C, Oh SY.   +5 more
europepmc   +1 more source