Results 171 to 180 of about 80,768 (254)

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

To Be FAIR: Theory Specification Needs an Update. [PDF]

Perspect Psychol Sci
Van Lissa CJ, Peikert A, Ernst MS, van Dongen NNN, Schönbrodt FD, Brandmaier AM.   +5 more
europepmc   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

From Picture Archiving and Communication System to AI production: development of a preprocessing pipeline for musculoskeletal radiological images from real-world data sources : results from the AI to Revolutionize the patient Care pathway in Hip and knEe aRthroplastY (ARCHERY) project. [PDF]

Bone Jt Open
Farrow L, Zhong M, Wilde K, Anderson L.
europepmc   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Stop Treating POCUS Like Radiology: Make It Part of the Physical Exam. [PDF]

PRiMER
Mortinsen R, Harris G, Prunuske J.
europepmc   +1 more source

Temperature Sensitivity and Adaptation of Cereal Yields: Empirical Evidence From Italy

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This paper investigates the evolving temperature sensitivity and climate adaptation of cereal yields in Italy from 1952 to 2023, using province‐level data for maize, common wheat, and durum wheat. Employing panel data econometric methods, we estimate yield responses to heat exposure, changes in sensitivity over time, and adaptation to climate ...
Paolo Nota, Giacomo Coughlan, Alessandro Olper   +2 more
wiley   +1 more source

The evolving role of DICOM in digital pathology. [PDF]

J Pathol Inform
Cornish TC, Dayal S, Ferber D, Chiweshe J, Monroe R.   +4 more
europepmc   +1 more source

Factors Affecting Recollapse of the Augmented Vertebrae After Percutaneous Vertebral Augmentation: A Prospective Study

AGING MEDICINE, EarlyView.
To investigate the relevant factors of augmented vertebrae recollapse after percutaneous vertebral augmentation (PVA) for the treatment of osteoporotic vertebral compression fractures (OVCFs). Intervertebral cleft (IVC) and those with PVP intervention are at higher risk of recollapse.
Yawen Zhang, Junchuan Liu, Maoyu Zhao, Yudian Qiu, Quan Ji, Nan Min, Qiang Wang   +6 more
wiley   +1 more source

Atypical Unilateral-Onset Guillain-Barré Syndrome Mimicking Acute Stroke: A Case Report. [PDF]

Cureus
Mobaideen D, Osman G, Nur A, Latif MF, Tayyib M.   +4 more
europepmc   +1 more source