Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Russia’s Security Perceptions and Arctic Governance
Politics and GovernanceRussia’s war in Ukraine further strained Russia’s relations with the West and negatively influenced Arctic regional governance, especially after seven members of the Arctic Council paused cooperation with Russia.
Angela Borozna
doaj +1 more source
Response to Rob Huebert's review of Diplomacy and the Arctic Council [PDF]
, 2021 Danita Catherine Burke
openalex +1 more source
Fate Control and Human Rights: The Policies and Practices of Local Governance in America's Arctic [PDF]
, 2014 The loss of territoriality over lands conveyed under the Alaska Native Claims Settlement Act had adverse impacts for Alaskan tribal governance. Despite policy frameworks that emphasize the value of local governance at an international, regional, and ...
Kimmel, Mara
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
An Independent Review of USGS Circular 1370: An Evaluation of the Science Needs to Inform Decisions on Outer Continental Shelf Energy Development in the Chukchi and Beaufort Seas, Alaska [PDF]
, 2011 Reviews the U.S. Geological Survey's findings and recommendations on Alaska's Arctic Ocean, including geology, ecology and subsistence, effect of climate change on, and impact of oil spills.
Alan Springer +13 more
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Little Fish, Big Pond: Icelandic Interests and Influence in Arctic Governance
Nordicum-Mediterraneum, 2016 The paper presents the Arctic Council and Iceland’s role within it before turning to issues that are governed outside of the Arctic Council system, in particular, Arctic fisheries and maritime boundaries.
Rachael L. Johnstone
doaj
Arktisk politik og regimedannelse i 2010'erne
Nordlit: Tidsskrift i litteratur og kultur, 2012 Recent developments have placed the High North on the international agenda. These include global warming, the prospects of major oil and gas finds, the opening of the Arctic Ocean to international shipping and the ongoing partition of its outer ...
Nikolaj Petersen
doaj +1 more source
Widespread decline in hydrological monitoring threatens Pan‐Arctic Research [PDF]
, 2002 Operational river discharge monitoring is declining in both North America and Eurasia. This problem is especially severe in the Far East of Siberia and the province of Ontario, where 73% and 67% of river gauges were closed between 1986 and 1999 ...
Lammers, Richard B. +2 more
core +2 more sources