Results 191 to 200 of about 43,979 (259)

Greenland Norse walrus exploitation deep into the Arctic. [PDF]

Sci Adv
Ruiz-Puerta EJ, Jarrett G, McCarthy ML, Pan SE, Keighley X, Aiken M, Zampirolo G, Loonen MJJE, Gotfredsen AB, Howse LR, Szpak P, Pálsson S, Rufolo S, Malmquist HJ, Desjardins SPA, Olsen MT, Jordan PD.   +16 more
europepmc   +1 more source

Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia

Advanced Science, EarlyView.
Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji, Yongli Ye, Jiadi Sun, Lina Sheng, Jinyou Li, Jin Yang, Bing Wu, Yuting Wang, Xingxing Gao, Liang Luo, Jianfeng Ping, Yinzhi Zhang, Xiulan Sun   +12 more
wiley   +1 more source

Migration to breeding areas by male sperm whales Physeter macrocephalus from the Northeast Atlantic Arctic. [PDF]

Sci Rep
Lydersen C, Blanchet MA, Kovacs KM, Similä T, Freitas C, Morange Z, Pedersen OM, Vogel EF, Bril M, Christensen G, Rikardsen AH.   +10 more
europepmc   +1 more source

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, EarlyView.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

Seafloor primary production in a changing Arctic Ocean. [PDF]

Proc Natl Acad Sci U S A
Attard K, Singh RK, Gattuso JP, Filbee-Dexter K, Krause-Jensen D, Kühl M, Sejr MK, Archambault P, Babin M, Bélanger S, Berg P, Glud RN, Hancke K, Jänicke S, Qin J, Rysgaard S, Sørensen EB, Tachon F, Wenzhöfer F, Ardyna M.   +19 more
europepmc   +1 more source

Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction

Advanced Science, EarlyView.
A microfluidic platform of engineered blood vessels is developed to study the role of mechanical forces in immune cell adhesion and extravasation in uremic microenvironments. Elevated pressure increases monocyte activity, with ICAM‐1 as a key driver. Matrix density influences monocyte phenotypes, but the uremic environment consistently promoted a pro ...
Mitesh Rathod, Ryan N. Stack, Sarah E. Kubik, Stephanie A. Huang, Chloe P. Whitworth, Wen Y. Aw, Elizabeth L. Doherty, Sara M. Meehan, Prabir Roy‐Chaudhury, William J. Polacheck   +9 more
wiley   +1 more source

Redefining Arctic boundaries in a changing climate: interdisciplinary perspectives on governance strategies. [PDF]

Polar Geogr (Palm Beach)
Nanni U, DeRepentigny P, Lundén A, Popovaitė V, Shen Y, Basaran IK, Duarte Neubern N, Mascorda-Cabre L, Bennett A, Vold Hansen T, Holmes FA, Kavvatha E, Meyer A, Prakash A, Wołoszyn A.   +14 more
europepmc   +1 more source

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

Rare bird forecast: A combined approach using a long-term dataset of an Arctic seabird and a numerical weather prediction model. [PDF]

Ecol Evol
Senzaki M, Tamura K, Watanabe Y, Watanabe M, Sato T.   +4 more
europepmc   +1 more source