Results 91 to 100 of about 933 (190)

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Measuring the Impact of the Substitution of Innovator Biologics With Biosimilars on Uptake and Costs Among Ontario Public Drug Benefit Recipients

Clinical Pharmacology &Therapeutics, EarlyView.
In Ontario, biologics have historically represented a small proportion of public drug claims but a large proportion of spending. Biosimilars, lower cost alternatives to biologics, offer a potential solution to the rising spending on biologics. From March 2023 to January 2024, the Ontario Ministry of Health required public drug program beneficiaries on ...
Anita Iacono, Martin K. H. Ho, Joanna Yang, Tonya Campbell, William Wynne, Dana Shearer, Lene Andersen, Eric Majer, Shaleesa Ledlie, Mina Tadrous, Tara Gomes   +10 more
wiley   +1 more source

China’s Arctic Policy in a Time of Global Geopolitical Transformation: A Northern Orientation

Vestnik RUDN. International Relations
Since the early 2000s, China has been putting consistent efforts to push its way into the Arctic and secure a position as an equal participant in international political and economic processes in the region.
Marina O. Rekets
doaj   +1 more source

Bioactivation and Metabolism of Amino Acid MDMA Prodrugs in Zebrafish Embryos, Human Liver S9, Whole Blood, and Microdosed Human Urine

Drug Testing and Analysis, EarlyView.
Bioactivation and metabolism of MDMA prodrugs: MDMA‐Trp, MDMA‐Lys, MDMA‐Gly showed unique urine screening targets only for MDMA‐Trp, while biomarkers for MDMA‐Lys and MDMA‐Gly consisted of MDMA and known MDMA metabolites. Conversion of amino acid prodrugs to MDMA in pHLS9, zebrafish embryos, and humans. ABSTRACT 3,4‐Methylenedioxymethamphetamine (MDMA)
Simon K. Wellenberg, Lea Wagmann, Matthias D. Kroesen, Philip Schippers, Matthias Grill, Jennifer Herrmann, Markus R. Meyer   +6 more
wiley   +1 more source

Arctic Policy: Learning from Current Arctic Strategies

, 2020
An Energy Academic Group (EAG) Intern Report. Updated June 2021 This report analyzes the similarities and differences of the military-oriented Arctic strategies for four Arctic states in order to understand common priorities and strengthen future US agencies' documents related to the region. During the research, we have identified overlapping goals and
openaire   +1 more source

Strengthening urban resilience in China through underground infrastructures management: Addressing global climate challenges with technological solutions

Deep Underground Science and Engineering, EarlyView.
This paper explores how climate‐resilient technologies, such as smart grids, digital twins, and self‐healing materials, can enhance urban resilience. It highlights the urgent need for proactive planning, public‐private collaboration, and data‐driven innovation to future‐proof underground infrastructure amid accelerating climate and urban pressures ...
Kai Chen Goh, Tonni Agustiono Kurniawan, Christia Meidiana, Abdelkader Anouzla, Faissal Aziz, Imran Ali, Joan Cecilia C. Casila, M. Imran Khan, Dongdong Zhang, Meihui Jiang, Mohd Hafiz Dzarfan Othman, Md Munir Hayet Khan, Kasun Kumara Dissanayake   +12 more
wiley   +1 more source

The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei

Developmental Dynamics, EarlyView.
Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Jeong Han Lee, Ebenezer N. Yamoah, Jennifer Kersigo, Karen Elliott, Niya LaRoda, Gabriela Pavlinkova, Bernd Fritzsch   +6 more
wiley   +1 more source

Participation of India in the Arctic Council

Арктика и Север
The purpose of the article is to examine India’s participation in the work of the Arctic Council by analyzing three criteria: the number of delegates sent by India to the meetings of the Arctic Council’s Senior Arctic Officials; the number of projects in
Darya N. Veselova
doaj   +1 more source

The Prevention of Eating Disorders in Australian Adolescents: A Modeled Cost‐Effectiveness Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Prevention programs for eating disorders (EDs) have the potential to reduce the onset of these diseases and improve the mental health and well‐being of the general population. However, there is mixed evidence on whether routine implementation of such programs at the population level is cost‐effective.
Long Khanh‐Dao Le, Eng Joo Tan, Phillipa Hay, Jaithri Ananthapavan, Yong Yi Lee, Cathrine Mihalopoulos   +5 more
wiley   +1 more source

Small States in World Politics: Norwegian Interests and Foreign Policy Challenges in the Arctic

Arctic Review on Law and Politics
Small states are perceived to be subject to the will of great powers in the international system. Yet, small states – such as Norway – also have interests they pursue through various means. This article features an inventory of the Norwegian government’s
Beate Steinveg
doaj   +1 more source