Results 61 to 70 of about 933 (190)

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

ARCTIC REGION AS GEOPOLITICAL SPACE OF THE XXI CENTURY

Проблемы постсоветского пространства, 2017
Article is devoted to research of geopolitical position of the Arctic region, its role in modern policy. Approaches of the Arctic countries and of the external regional states to realization of policy in the Arctic are considered. Geopolitical rivalry in
A. I. Morozov
doaj  

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

Advanced Science, EarlyView.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka, Yuhei Higashi, Suguru Saito, Solmaz Pourgonabadi, Honami Honjoh, Sho Ishigaki, Peter C. Harris, Lisa M. Satlin, Michifumi Yamashita, Ryuji Morizane   +9 more
wiley   +1 more source

WHAT REGION IN THE ARCTIC HAS THE BEST CONDITIONS FOR THE IMPLEMENTATION OF REGIONAL INDUSTRIAL POLICY MEASURES?

Север и рынок: формирование экономического порядка, 2023
This article addresses the research question concerning the assessment of current prerequisites for implementing industrial policy within the Arctic territories of Russia through the efforts of local and regional authorities.
Alexandr N. Pilyasov, Vyacheslav A. Tsukerman   +1 more
doaj   +1 more source

Emerging Advanced Electronic Packaging Materials for Thermal Management in Power Electronics

Advanced Science, EarlyView.
This review surveys emerging materials for thermal management in advanced electronic packaging, with emphasis on ceramic substrates and thermal interface materials. Multiscale simulations and mechanistic analyses are highlighted, alongside the emerging role of artificial intelligence in predicting thermal properties and guiding design, offering ...
Yongjun Huo, Jiaqi Song, Wenqian Li, Jian Zhang, Yujin Zhang, Yang Fu, Wangchao Yuan, Xin Chen, Sichen Liu, Miao Jiang, Yuan Cheng, Gang Zhang   +11 more
wiley   +1 more source

ARCTIC ENERGY POLICY AND SECURITY OF THE RUSSIAN FEDERATION

Security and Defence Quarterly, 2016
In this article, the author examines the Arctic region in the context of the energy and security policy of the Russian Federation. The author emphasises the factors which currently influence the increasing interest in the Arctic of the countries which ...
Marcin Urbański
doaj   +1 more source

Climate Change Agricultural Comparative Advantage and the US Trade Balance

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Current science indicates that warming and elevated atmospheric CO2 will have ambiguous results for crop productivity depending on crop type and geographic location, whereas increased heat stress makes livestock and human labor less productive.
Elizabeth A. Fraysse, Thomas W. Hertel, Roman Keeney   +2 more
wiley   +1 more source

Relationships among tissues, biofluids, and otolith selenium concentrations in wild female burbot (Lota lota)

Integrated Environmental Assessment and Management, EarlyView., 2023
Abstract In the Lake Koocanusa‐Kootenai River system (Montana, USA and British Columbia, Canada), selenium (Se) contamination has become an international concern and is suspected to contribute to the observed burbot (Lota lota) population collapse. Due to our limited ability to sample burbot in Lake Koocanusa for monitoring studies, we used a reference
Stephanie D. Graves, Noëlie Molbert, David M. Janz, Lauren D. Hayhurst, Jessica E. Brandt, Lauren Timlick, Vince P. Palace   +6 more
wiley   +1 more source

The Bitter Taste of Brazil's Temporary Import Ban on Robusta Coffee

Agribusiness, EarlyView.
ABSTRACT Brazil, a leading Robusta coffee producer and exporter, faced a significant drought in 2016–2017, which drastically reduced production and depleted stocks. Consequently, Brazil temporarily permitted the import of one million 60‐kg bags of Robusta coffee in the spring 2017. An import ban was imposed shortly afterward due to lobbying by domestic
Hanifi Otgun, John Beghin, Fernando Maximiliano   +2 more
wiley   +1 more source