Results 61 to 70 of about 4,460,604 (284)
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Advanced Science, EarlyView.Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
Political Vector of Northern Sea Route Development
Vestnik MGIMO-Universiteta, 2015 In this article the author considers the issue of exploitation of Arctic region, especially of NSR. This transport corridor is very important from geopolitical point of view.
Andrei A. Fomichev
doaj +2 more sources
INTERNATIONAL LEGAL FRAMEWORK OF THE ARCTIC POLICY OF THE PEOPLE’S REPUBLIC OF CHINA
Московский журнал международного права, 2018 INTRODUCTION. The article contains analysis of the main international legal documents on which the Arctic policy of the People’s Republic of China is based.
E. V. KIENKO
doaj +1 more source
Advanced Science, EarlyView.A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang +5 more
wiley +1 more source
Newcomers of the Arctic Council open the Far North [PDF]
Арктика и Север, 2016 The article is devoted to the study of the elaboration and realization of the Arctic policy in three countries - members of the EU. These are Netherlands, Poland and Spain.
Natalia M. Antyushina
doaj +1 more source
Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields
Advanced Science, EarlyView.Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng +71 more
wiley +1 more source
Arctic Offshore Oil and Gas Guidelines [PDF]
, 2009 The Ministers of the Arctic States—Canada, Denmark, Iceland, Finland, Russia, Sweden, Norway and the United States of America— originally adopted the Guidelines at the Fourth Ministerial Conference on the Protection of the Arctic Environment, 11-12 June,
Arctic Council, Protection of the Arctic Marine Environment (PAME)
core +1 more source
Prospects for the development of the agro-industrial complex in the arctic territories: Domestic and foreign experience [PDF]
E3S Web of ConferencesCurrently, the political, military and economic interests in the territories belonging to the Arctic zone are at the peak of the interests of many states.
Belousov Sergey +4 more
doaj +1 more source
Арктика и Север, 2016 The article describes the evolution of the British Arctic strategy, the role of the British political institutions in this process, as well as the interests and policy priorities for the region. It is noted that currently the focus of the UK is addressed to the study of the environment state in the Arctic, as well as on climate change.
Elena V. Ananieva, Natalia M. Antyushina
openaire +1 more source
Advanced Science, EarlyView.In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian +13 more
wiley +1 more source