Results 101 to 110 of about 5,683,359 (349)

Cryptosporidium hominis Is a Newly Recognized Pathogen in the Arctic Region of Nunavik, Canada: Molecular Characterization of an Outbreak

PLoS Neglected Tropical Diseases, 2016
Background Cryptosporidium is a leading cause of childhood diarrhea in low-resource settings, and has been repeatedly associated with impaired physical and cognitive development.
Karine Thivierge, A. Iqbal, B. Dixon, R. Dion, B. Lévesque, P. Cantin, L. Cédilotte, M. Ndao, J. Proulx, C. Yansouni   +9 more
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Soviet experience of development of the Soviet Arctic in view of modern problems. Review of Zubkov K.I., Karpov V.P. Development of the Russian Arctic: Soviet experience in the context of current national strategy (on the example of the Ural Far North and Western Siberia). Moscow: Political encyclopedia, 2019. 367 p.

Вестник археологии, антропологии и этнографии, 2020
Discussed in this review are the results of the research presented in the monograph of specialists in North-ern studies K.I. Zubkov and V.P. Karpov «Development of the Russian Arctic: Soviet experience in the context of current national strategy (on the ...
M.G. Agapov
doaj   +1 more source

The impact of a seasonally ice free Arctic Ocean on the temperature, precipitation and surface mass balance of Svalbard [PDF]

, 2012
The observed decline in summer sea ice extent since the 1970s is predicted to continue until the Arctic Ocean is seasonally ice free during the 21st Century. This will lead to a much perturbed Arctic climate with large changes in ocean surface energy flux.
Bamber, Jonathan L, Day, Jonathan J, Kohler, Jack, Valdes, Paul J   +3 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Potential climatic transitions with profound impact on Europe [PDF]

, 2011
We discuss potential transitions of six climatic subsystems with large-scale impact on Europe, sometimes denoted as tipping elements. These are the ice sheets on Greenland and West Antarctica, the Atlantic thermohaline circulation, Arctic sea ice, Alpine
A Born, A Ganachaud, A Ganopolski, A Hu, A Jones, A Laurian, A Levermann, A Levermann, A Levermann, A Levermann, A Schmittner, A Winguth, AA Scaife, Anders Levermann, Andrey Ganopolski, B Dickson, B Schaefli, B Zwierl, BJ Soden, BN Goswami, C Deser, C Haas, C Harris, C Schnadt, C Schoof, C Stick, C Vincent, CAPE-Last Interglaicial Project Members, CL Parkinson, D Farinotti, D Notz, D Pollard, D Stammer, DA Lashof, DA Rothrock, DB Kirk-Davidoff, DG Vaughan, Dirk Notz, DK Perovich, DM Holland, DM Lawrence, DT Shindell, DWJ Thompson, E Kriegler, E Meur Le, E Rignot, E Rignot, E Rignot, EJ Rignot, F Paul, F Paul, G Cogley, G Jouvet, G Kaser, G Manney, G Manney, G Manney, GA Meehl, GJ Oldenborgh van, H Goosse, H Hátún, HD Pritchard, HJ Schellnhuber, I Auer, I Eisenmann, I Joughin, I Joughin, I Velicogna, J Maslanik, J Noetzli, J Oerlemans, J Oerlemans, J Oerlemans, J Ridley, J Ridley, J Stroeve, J Weertman, J Yin, J Yin, J Zhang, JA Church, JC Comiso, JE Kay, JF McManus, JH Jungclaus, JL Bamber, JL Chen, JM Gregory, JM Gregory, Jonathan L. Bamber, JP Wilkinson, JR Miller, JT Overpeck, JX Mitrovica, K Eckhardt, K Zickfeld, KH Rosenlof, Kirstin Krüger, LC Sime, LH Smedsrud, M Beniston, M Dameris, M Hoelzle, M Hofmann, M Honda, M Huss, M Huss, M Huss, M Ogi, M Rex, M Rex, M Scheffer, M Stendel, M Vellinga, M Vellinga, M Wang, M Winton, M Winton, M Zemp, M Zemp, Matthias Huss, MF Meier, MM Holland, Neil R. P. Harris, NP Harris, NW Arnell, O Solomina, P Huybrechts, P Wadhams, P Wadhams, P Wadhams, Peter Wadhams, PM Forster, PU Clark, R Hock, R Lindsay, RE Kopp, RJ Braithwaite, RJ Stouffer, Ronald W. Lindsay, RP Scherer, S Amstrup, S Gruber, S Rahmstorf, S Rahmstorf, S Rahmstorf, S Rahmstorf, S Rahmstorf, S Solomon, S Solomon, S Tegtmeier, S Tietsche, SJ Evans, SJ Oltmans, SL Weber, SL Weber, SS Drijfhout, Susanne Weber, Sybren Drijfhout, T Hattermann, T Kuhlbrodt, T Naish, T Toniazzo, Timothy M. Lenton, TM Lenton, V Petoukhov, VM Kattsov, W Haeberli, W Haeberli, W Weijer, Winfried Haeberli, WJ Randel, WT Pfeffer, Y Wang, ZW Kundzewicz   +174 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The increase of an allelopathic and unpalatable plant undermines reindeer pasture quality and current management in the Norwegian tundra

Communications Earth & Environment
Ongoing Arctic greening can increase productivity and reindeer pasture quality in the tundra. However, greening may also entail proliferation of unpalatable species, with consequences for pastoral social-ecological systems.
Maria W. Tuomi, Tove Aagnes Utsi, Nigel Gilles Yoccoz, Claire W. Armstrong, Victoria Gonzalez, Snorre B. Hagen, I. S. Jónsdóttir, Francisco I. Pugnaire, Katriona Shea, David A. Wardle, Sophia Zielosko, Kari Anne Bråthen   +11 more
doaj   +1 more source

Ozone loss derived from balloon-borne tracer measurements in the 1999/2000 Arctic winter [PDF]

, 2005
Balloon-borne measurements of CFC11 (from the DIRAC in situ gas chromatograph and the DESCARTES grab sampler), ClO and O3 were made during the 1999/2000 Arctic winter as part of the SOLVE-THESEO 2000 campaign, based in Kiruna (Sweden).
A. D. Robinson, A. Engel, A. M. Lee, D. W. Toohey, E. Ray, F. Danis, F. Goutail, F. Moore, G. A. Millard, H. Nilsson, J. A. Pyle, J. A. Pyle, J. Arvelius, J. D. McIntyre, J. W. Elkins, J.-P. Pommereau, M. Guirlet, M. Müller, N. R. P. Harris, S. Dagnesjo, S. Kirkwood, T. Deshler, U. Schmidt   +22 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source