Results 121 to 130 of about 5,683,359 (349)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Modernization of the Arctic system of mineral resources' transportation [PDF]

open access: yesVestnik MGTU, 2015
The approaches to definition of concept "region" existing in the economic science have been systematized. The region of the Western Arctic has been singled out on the basis of localization of copper-nickel ores' fields, objects of the Arctic nickel ...
Savel'eva S. B., Grin Yu. A.
doaj  

CREATIVE INDUSTRIES IN THE ARCTIC: A REVIEW OF RUSSIAN SCIENTIFIC LITERATURE

open access: yesСевер и рынок: формирование экономического порядка, 2021
The article reviews the points of view of Russian researchers on the development of creative industries in the Arctic. The main issues that are considered by domestic authors in the works on the development of creative industries in the Russian Arctic ...
Artur S. Krasil’nikov
doaj   +1 more source

Social inequalities in health in the Arctic region: from observing to serving. [PDF]

open access: yesScand J Public Health, 2023
Lundblad MW, Broderstad AR, Njølstad I.
europepmc   +1 more source

Sequencing of rabies binding region on nicotinic acteylcholine receptor alpha subunits in four host species [PDF]

open access: yes, 2013
• Rabies virus is known to bind to nicotinic acetylcholine receptors (nAchR) • The virus is known to bind to alpha 1 subunits nAchR • The virus binding region has been characterized in alpha 1 subunits of these receptors • Little research has been ...
Barnard, Karen
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Political geographies of the ‘changing’ Arctic: perspectives on the interface between politics and the region as a process

open access: yesNordia Geographical Publications, 2020
This thesis discusses the political geographies of the ‘changing’ Arctic from the perspective of regional theory. Concurrently it explores the contributions that empirical research on these geographies can provide for regional theory and political ...
Vesa Väätänen
doaj  

Seismicity, structure and tectonics in the Arctic region

open access: yes, 2015
The “Arctic” region, where the North Pole occupies the center of the Arctic Ocean, has been affecting the environmental variation of the Earth from geological time to the present.
M. Kanao   +3 more
semanticscholar   +1 more source

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