Results 141 to 150 of about 3,061,171 (419)

Significant parameters of mining properties in arctic and subarctic areas of North America [PDF]

open access: yes, 1983
Editors: Bruce W. Campbell and John J. DiMarchiThis paper is a review of those factors unique to mining in the Arctic and subarctic. The information was developed from an exhaustive Literature search and personal visits to several northern mines in ...
Hackney, D.A., Lambert, C.
core  

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Community Response Strategies for Environmental Problems of Water Supply and Wastewater Disposal in Fairbanks, Alaska [PDF]

open access: yes, 1975
This report examines the history of the response strategies of the Fairbanks, Alaska, community to problems of water supply and wastewater disposal.
Pearson, Roger W., Smith, Daniel W.
core  

Arctic tree rings as recorders of variations in light availability [PDF]

open access: yes, 2014
Annual growth ring variations in Arctic trees are often used to reconstruct surface temperature. In general, however, the growth of Arctic vegetation is limited both by temperature and light availability, suggesting that variations in atmospheric ...
Huybers, P., Stine, A. R.
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Adaptation of NEMO-LIM3 model for multigrid high resolution Arctic simulation [PDF]

open access: yes, 2018
High-resolution regional hindcasting of ocean and sea ice plays an important role in the assessment of shipping and operational risks in the Arctic Ocean. The ice-ocean model NEMO-LIM3 was modified to improve its simulation quality for appropriate spatio-temporal resolutions. A multigrid model setup with connected coarse- (14 km) and fine-resolution (5
arxiv   +1 more source

Effect of solar activity on the frequency of occurrence of major anomalies in the Arctic [PDF]

open access: yes
Major air pressure and temperature anomalies in certain arctic regions were studied with a view toward predicting their occurrence. Correlations are sought between the frequency of arctic anomalies and solar activity, or specifically the Wolf number and ...
Bolotinskaya, M. S.
core   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

Boundaries of photosynthesis: adaptations of carbon fixation in extreme environments

open access: yesFEBS Open Bio, EarlyView.
Photosynthesis faces challenges from environmental extremes of temperature, pH, and salinity, limiting gas diffusion, modifying membrane fluidity, and destabilizing photochemical and biochemical reactions. Photosynthetic organisms have evolved unique adaptations overcoming these stresses and maintaining their photosynthetic activity.
Pere Aguiló‐Nicolau   +3 more
wiley   +1 more source

Foxes and food subsidies: anthropogenic food use by red and Arctic foxes, and effects on Arctic fox survival, on the Arctic Coastal Plain of Alaska [PDF]

open access: yes, 2013
Thesis (M.S.) University of Alaska Fairbanks, 2013Food subsidies have the potential to impact wildlife on the Arctic Coastal Plain of Alaska. Red foxes (Vulpes vulpes (L., 1758)) expanded their range into Arctic regions during the 20th century, and the ...
Savory, Garrett
core  

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