Results 41 to 50 of about 12,255 (265)

Status and trends in the structure of Arctic benthic food webs [PDF]

open access: yesPolar Research, 2015
Ongoing climate warming is causing a dramatic loss of sea ice in the Arctic Ocean, and it is projected that the Arctic Ocean will become seasonally ice-free by 2040.
Monika Kędra   +13 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Pathogenetic assessment of external respiratory function disturbance and is interrelation with BDNF gene polymorphism in military servicemen in extreme conditions of the Arctic zone

open access: yesРоссийская Арктика, 2023
Relevance. To date, the etiopathogenesis of polar hypoxia and its relationship with polymorphismes genes have not been fully studied. The aim of the study is to study the pathogenesis of ventilation disorders and polar hypoxia and their relationship ...
Lemeshchenko A.V.   +3 more
doaj   +1 more source

Morphogenetic classification of the Arctic coastal zone [PDF]

open access: yesGeo-Marine Letters, 2004
Arctic coastal evolution is the result of interactions between exogenic and endogenic processes. In the arctic region, this evolution differs from that in other areas of the world’s oceans as a result of interactions between modern wave and ice factors, and the influences of glaciations and large-scale sea level changes in the past. Geologic structure,
S. L. Nikiforov   +6 more
openaire   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Major demographic tendencies of the Arctic and sub-arctic zone of Russia

open access: yesYakut Medical Journal, 2019
№2(66) (2019)
K.V. Shelygin   +2 more
openaire   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

open access: yesFEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley   +5 more
wiley   +1 more source

Initial colonization of the Arctic zone

open access: yesComptes Rendus Palevol, 2006
Abstract Human colonization of the Arctic zone constitutes one of the most beautiful illustrations of the thesis according which human history, particularly in its early stages, represents a continuum of adaptations. The study of archaeological sites of North Fennoscandia has brought numerous evidences since the Mesolithic period.
openaire   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

open access: yesFEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez   +4 more
wiley   +1 more source

Morphology, Transport, and Dynamics of Protein Adsorption in Open‐Cell Metal Foam

open access: yesAdvanced Engineering Materials, EarlyView.
Stainless steel (SS) open‐cell foams are shown to adsorb more protein per unit area than previously reported 316L SS and chromium oxide surfaces under static and flow conditions. An integrated approach combining 3D pore imaging, flow simulation, and protein adsorption experiments characterizes the foam’s performance.
Chinmaya Prerana Inguva   +2 more
wiley   +1 more source

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