Results 71 to 80 of about 19,311,004 (300)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

THE PRESENT CONDITION AND PROSPECTS OF MILLET SEED-GROWING IN THE ORENBURG REGION

open access: yesЗерновое хозяйство России, 2018
The article has presented the analysis of varietal sowings in the Orenburg region during 2009-2013. It has estimated the change of a share of varietal and row sowings of millet.
L. A. Mukhitov, A. A. Zorov
doaj  

Calculus of variations and its application to division of forest land

open access: yesJournal of Forest Science, 2004
The paper deals with an application of the least squares method (LSM) for the purposes of division and evaluation of land. This method can be used in all cases with redundant number of measurements, in this case of segments of plots.
M. Matějík
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Cartographic Line Generalization Based on Radius of Curvature Analysis

open access: yesISPRS International Journal of Geo-Information, 2018
Cartographic generalization is one of the important processes of transforming the content of both analogue and digital maps. The process of reducing details on the map has to be conducted in a planned way in each case when the map scale is to be reduced.
Bogdan Kolanowski   +2 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

14th December (1.28MB) [PDF]

open access: yes, 2000
NAHB ...
Northern Area Health Board (NAHB)
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

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