Results 121 to 130 of about 222,748 (268)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

[Unequal impact of COVID-19 on mortality in long-term care homes across health areas of Castilla-La Mancha (Spain)]. [PDF]

An Sist Sanit Navar
Zunzunegui Pastor MV, Rubio Mengual I, Villar Baile Á, García López FJ.   +3 more
europepmc   +1 more source

IMPLICACIONES DEL TERREMOTO DEL 10 DE OCTUBRE EN EL AMBIENTE DEL AREA METROPOLITANA

La Universidad, 2018
El referirse at ambiente lleva obligadamente a una definición del mismo Según Tansley (citado por Hedström) son las "condiciones externas y el conjunto de elementos naturales que ejercen influencia sobre los organismos" Cuando dicha influencia se vislumbra en formas de relaciones interactuantes entre el ambiente y los organismos (incluyendo al hombre ...
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Elevated sCD25 predicts early infection in patients with major burns. [PDF]

Crit Care
Hurtado-Navarro L, Flores-Cabeza E, Mata-Martínez P, Sánchez-Sánchez M, Terrón-Arcos V, Martín-Flórez C, Cachafeirio L, Vejo-Gutiérrez J, Fernández-Felipe J, Lozano-Rodríguez R, Córdoba L, de Santa María-Diez GS, Del Prado-Montero J, Rigor-Pérez JG, de Diego RP, Del Fresno C, Cueto FJ, López-Collazo E.   +17 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Association between physical fitness and anthropometric indicators according to area of residence in Chilean adolescents: a cross-sectional study. [PDF]

BMJ Open
Yáñez-Sepúlveda R, Clemente-Suárez VJ, Mahecha-Matsudo S, Cortés-Roco G, de Souza-Lima J, Zavala-Crichton JP, Hinojosa-Torres C, Páez-Herrera J, Hurtado-Almonacid J, Reyes-Amigo T, Olivares-Arancibia J, Molina-Pedernera C, Aguilera-Martínez N, Tuesta M, López-Gil JF.   +14 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Genetic Status of the Northernmost Population of the Endangered and Elusive Huemul Deer, <i>Hippocamelus bisulcus</i>. [PDF]

Animals (Basel)
Marín JC, Venegas C, Morales GF, Monroy AP, Vásquez JP, López Rübke RA, Hinojosa Sáez AC, Chávez A, Johnson WE, Orozco-terWengel P.   +9 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source