Results 61 to 70 of about 11,092,458 (299)

Studies of Gamma Ray Sources with the Fermi Large Area Telescope [PDF]

, 2010
With its excellent sensitivity, large field of view, broad energy coverage, and good per-photon angular resolution, the Large Area Telescope aboard the Fermi Gamma-ray Space Telescope satellite provides us with an unprecedented view of the high-energy ...
Knödlseder, Jürgen
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Socioeconomic indicators of health inequalities and female mortality: a nested cohort study within the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) [PDF]

, 2015
Evidence is mounting that area-level socioeconomic indicators are important tools for predicting health outcomes. However, few studies have examined these alongside individual-level education. This nested cohort study within the control arm of the United
Apostolidou, S, Bailey, K, Burnell, M, Fourkala, E, Gentry-Maharaj, A, Jacobs, I, Kalsi, J, Menon, U, Parmar, M, Pikhart, H, Ryan, A   +10 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Syntactic structure and artificial grammar learning : The learnability of embedded hierarchical structures [PDF]

, 2008
Embedded hierarchical structures, such as ‘‘the rat the cat ate was brown’’, constitute a core generative property of a natural language theory. Several recent studies have reported learning of hierarchical embeddings in artificial grammar learning (AGL)
de Vries, M.H., Knecht, S., Monaghan, P., Zwitserlood, P.   +3 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Identification of generic errors for effective formative feedback in energy studies thematic area of mechanical engineering [PDF]

, 2012
The paper describes the findings from a CETL funded project for the identification of generic errors made by undergraduate students within the thematic area of energy studies in an accredited Mechanical Engineering programme.
Hasan, Reaz
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

“Telling it in our own way”: Doing music-enhanced interviews with people displaced by violence in Colombia

New Area Studies, 2020
In Colombia, five decades of violent conflict have displaced millions of people, many of whom now face severe risks from flooding, landslides and other environmental hazards in the places they have found to resettle.
Hazel Marsh, M. Teresa Amijos, Roger Few
doaj   +1 more source

Supporting Research in Area Studies: a guide for academic libraries [PDF]

, 2015
The study of other countries or regions of the world often crosses traditional disciplinary boundaries in the humanities and social sciences. Supporting Research in Area Studies is a comprehensive guide for academic libraries supporting these communities
Pitman, L
core