Results 151 to 160 of about 270,097 (301)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Sembrando granitos de arena : notas del gran mundo de la gente menuda

, 1930
Fecha de prelim., 1930Data de prelim ...
Manuel González , Santo, 1877-1940
core  

Individuality across environmental context in <i>Drosophila melanogaster</i>. [PDF]

Elife
Mathejczyk TF, Knief C, Haidar MA, Freitag F, McClary T, Wernet MF, Linneweber GA.   +6 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Public Sphere and Civil Society? Transformations of the European Union

, 2007
No abstract ...
Schlesinger, Philip, Kværk, Geir Ove, Fossum, John Erik   +2 more
core  

Olfactory learning in two Amblypygi species Paraphrynus laevifrons and Phrynus pseudoparvulus. [PDF]

Anim Cogn
Segura-Hernández L, Lehmann KDS, Perez J, Wiegmann DD, Bingman VP, Hebets EA.   +5 more
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Arena 2006, Acoustic and Radio EeV Neutrino Detection Activities

, 2006
The International Conference on Acoustic and Radio EeV Neutrino Activities, ARENA 2006 was jointly hosted by the Universities of Northumbria and Sheffield at the City of Newcastle Campus of the University of Northumbria in June 2006.
CAPONE, Antonio, J. Perkin, J. Blümer, D. Besson, S. Danaher, J. Learned, C. Rhodes, G. Gratta, R. Nahnhauer, F. Halzen, F. Vannucci, P. Gorham, D. Saltzberg, G. Anton, L. Thompson, T. Sloan, A. Rostovtzev, D. Waters, H. Falcke   +18 more
core  

The protective value of the size and movement components of deimatic behavior. [PDF]

Behav Ecol
Hämäläinen L, Marsland CM, White TE, Rowland HM, Umbers KDL.   +4 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source