Results 51 to 60 of about 255,561 (311)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Synergistic Development, Test, and Qualification Approaches for the Ares I and V Launch Vehicles [PDF]

, 2009
The U.S. National Aeronautics and Space Administration (NASA) initiated plans to develop the Ares I and Ares V launch vehicles in 2005 to meet the mission objectives for future human exploration of space.
Bartolotta, Paul, Cockrell, Charles E., Goggin, David, Huetter, Uwe, Kaderback, Don, Patterson, Alan, Stephens, Samuel E., Taylor, James L., Tuma, Margaret   +8 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

CBRNe Personal Protective Equipment Is Not a Hindrance to Lifesaving Procedures in Prehospital Settings: A Prospective, Repeated-Measures Observational Study

Epidemiologia
Objectives: The primary objective was to compare the usage of Hazardous Materials (HazMat) Protective Personal Equipment (PPE) and ordinary PPE when performing basic and advanced health care support maneuvers in a prehospital setting, evaluating the ...
Stefano Innocenzi, Fabio Ingravalle, Massimo Maurici, Daniela Di Rienzo, Danilo Casciani, Michelangelo Cesare Rinella, Antonio Vinci, Eliana Giuffré, Nicoletta Trani, Stefania Iannazzo, Narciso Mostarda   +10 more
doaj   +1 more source

Space Operations for a New Era of Exploration Launch Vehicles [PDF]

, 2010
Since 2005, Ares has made substantial progress on designing, developing, and testing the Ares I crew launch vehicle and has continued its in-depth studies of the Ares V cargo launch vehicles. The combined Ares I/Ares V architecture was designed to reduce
Davis, Daniel J.
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Ares V: A National Launch Asset for the 21st Century [PDF]

, 2009
NASA is designing the Ares V as the cargo launch vehicle to carry NASA's exploration plans into the 21st century. The Ares V is the heavy-lift component of NASA's dual-launch architecture that will replace the current space shuttle fleet, complete the ...
Creech, Steve, Sumrall, Phil
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

ARES

Revista Brasileira de Medicina de Família e Comunidade
Introdução: A Universidade Aberta do Sistema Único de Saúde (UNASUS) é uma estratégia de educação permanente em saúde pela educação a distância (EaD).
Josué Miguel de Oliveira, François Isnaldo Dias Caldeira, Lucas Ribeiro Monteiro, Kellen Cristina da Silva Gasque   +3 more
doaj   +1 more source

Occurrence of Fusarium wilt and Twospotted Spider Mite under Plastic Mulched and Non-Plastic Mulched Bed in Hydroponic Culture of Strawberry

Research in Plant Disease, 2018
Hydroponic strawberry culture system is increasing annually. Most of strawberry farmers use mulched bed in hydroponic culture and strawberry plants were transplanted in early September.
Myeong Hyeon Nam, Hyun Sok Kim, Tae Il Kim, Sang-Keun Oh   +3 more
doaj   +1 more source