Results 121 to 130 of about 7,615 (291)

PENGARUH MODEL ARGUMENT DRIVEN INQUIRY TERHADAP KEMAMPUAN BERPIKIR TINGKAT TINGGI BERDASARKAN PERBEDAAN GAYA BELAJAR SISWA SMP PADA MATERI SISTEM EKSKRESI

, 2022
This study aims to determine the effect of the Argument Driven Inquiry learning model on higher-order thinking skills based on the learning style of VIII grade junior high school students on the excretory system material.
Juhanda, Aa, Nuranti, Gina, Hidayanti, Nurfitri   +2 more
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Effect of Argument Driven Inquiry (ADI)-STEM Model on Students' Numeracy Literacy and Scientific Argumentation Skills

Jurnal Penelitian Pendidikan IPA
This study aims to determine the significant effect of the argument driven inquiry (ADI)-STEM learning model on numeracy literacy and scientific argumentation skills of students on the subject matter of dynamic fluid class XI semester II at SMAN 10 Medan T.P 2024/2025.
Laia, Syukurman, Siregar, Nurdin, Simanjuntak, Mariati Purnama   +2 more
openaire   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Pengaruh Model Pembelajaran Argument-Driven Inquiry Terhadap Keterampilan Argumentasi Siswa

, 2018
This study aims to determine the significance of the influence of the use of Argument-Driven Inquiry (ADI) learning models, students' academic abilities, and the interaction between learning models and academic abilities towards student argumentation ...
Hasnunidah, Neni, Sikumbang, Darlen, Ningtyas, Ninda   +2 more
core  

Penerapan Model Pembelajaran Argument Driven Inquiry (ADI) Untuk Melatihkan Kemampuan Argumentasi Ilmiah Peserta Didik SMA

, 2019
Argumentasi ilmiah adalah sebuah usaha untuk memvalidasi ataupun menolak sebuah gagasan yang didasarkan pada sebuah alasan ilmiah yang mencermikan perilaku para ilmuwan.
HANIFAH, NUR, ADMOKO, SETYO
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source