Results 231 to 240 of about 81,568 (293)

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source

Free to err? Conceptualising personal autonomy in the postpandemic welfare state. [PDF]

Glob Bioeth
Sørensen M, Di Nucci E, Jørgensen KJ, Greisen G.   +3 more
europepmc   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Creative and Critical Thinking and Modelling: Confluences and Implications for Science Teaching. [PDF]

J Intell
Gómiz-Aragón M, Aragón-Méndez MDM, Vieira RM, Tenreiro-Vieira C, Oliva JM.   +4 more
europepmc   +1 more source

Improving Argumentative Writing in School

The Annual Report of Educational Psychology in Japan, 2019
openaire   +2 more sources

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

When collaboration fails: persuasion driven adversarial influence in multi agent large language model debate. [PDF]

Sci Rep
Kraidia I, Qaddara I, Almutairi A, Alzaben N, Belhouari SB.   +4 more
europepmc   +1 more source

Beyond words: understanding anxiety and depression in college applicants through LIWC analysis of textual features. [PDF]

Front Psychol
Abutara A, Kissimoto A, de Aguiar FO, Otani V, Uchida RR, Marques LM.   +5 more
europepmc   +1 more source

Author or prompter? Scientific writing, identity, and the Theseus paradox. [PDF]

Philos Ethics Humanit Med
Akgün M.
europepmc   +1 more source

Generative artificial intelligence: the 'more knowledgeable other' in a social constructivist framework of medical education. [PDF]

NPJ Digit Med
Tran M, Balasooriya C, Semmler C, Rhee J.   +3 more
europepmc   +1 more source