Results 131 to 140 of about 1,029,823 (374)

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

open access: yesAdvanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su   +15 more
wiley   +1 more source

Multicharged Zwitterions form Superior Antifouling Interfaces

open access: yesAdvanced Science, EarlyView.
Bolaamphiphilic multicharged sulfobetaine zwitterion forms self‐assembled monolayer for antifouling applications and vesicular aggregates for drug delivery applications. Abstract The long‐term prevention of unwanted protein and microbial accumulation on surfaces, including medical devices, remains a significant and largely unresolved challenge. Decades
Declan Meehan   +6 more
wiley   +1 more source

Systematic Benchmarking of a Noise‐Tolerant Conductive Hydrogel Electrode for Epidermal Bioelectronics

open access: yesAdvanced Science, EarlyView.
General schematic of the approach. Abstract Conventional Silver/Silver Chloride (Ag/AgCl) electrodes remain the clinical standard for electrophysiological monitoring but are hindered by poor skin conformity, mechanical rigidity, and signal degradation, particularly under motion or sweat.
Nazmi Alsaafeen   +11 more
wiley   +1 more source

Proses Berpikir Calon Guru Matematika dalam Memecahkan Masalah Geometri Transformasi Berdasarkan Teori John Dewey

open access: yesArithmetic
Understanding the thinking process of students has great significance, how students face and solve transformation geometry problems not only reflects the understanding of concepts, but also the ability to think systematically, creatively, and logically ...
Fauzanah Fauzanah, Putri Nur Malasari
doaj   +1 more source

Precise Construction of an Antimicrobial Peptide Targeting Bacterial Cell Membranes Derived From Natural Peptides

open access: yesAdvanced Science, EarlyView.
An AMP (P 3‐3R‐8I) based on natural peptides, which can target bacterial cell membranes, was precisely constructed via amino acid mutation. P 3‐3R‐8I exhibits antibacterial capability which could be attributed to the ability of P 3‐3R‐8I to quickly penetrate bacterial cell membranes and then to bind to bacterial DNA.
Jiaqi Huang   +11 more
wiley   +1 more source

Effectiveness: Integrated Mathematics Module of the al-Qur'an and Hadith with Internalization of Madurese Culture and Religious Moderation

open access: yesArithmetic
Bilangan pecahan merupakan salah satu topik matematika yang dianggap sulit oleh peserta didik. Hal ini sejalan dengan data di lapangan bahwa pemahaman peserta didik pada tingkat Sekolah Dasar terhadap konsep pecahan masih sangat rendah. Tujuan penelitian
Dewi Rosikhoh   +3 more
doaj   +1 more source

From Complex Shaping to Mirror Finish: Additive Manufacturing of Aerospace‐grade Cf/SiC Space Optics

open access: yesAdvanced Science, EarlyView.
An integrated additive manufacturing route combines selective laser sintering, engineered interphases, and optimized silicon infiltration to fabricate complex Cf/SiC composites. The approach enables precise shaping, high mechanical performance, and excellent optical reflectivity, offering a scalable solution for advanced aerospace optics with both ...
Buhao Zhang   +8 more
wiley   +1 more source

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