Results 261 to 270 of about 177,679 (314)

Safety and Pharmacokinetics of Long‐Acting Monoclonal Antibodies Tixagevimab and Cilgavimab (AZD7442) in a China Phase 2 Study and Evaluation of Asian Race Effect

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Safety, pharmacokinetics, and impact of race of pharmacokinetics on monoclonal antibodies tixagevimab and cilgavimab (AZD7442) were assessed in Chinese adult participants in a Phase 2, randomized, double‐blind, placebo‐controlled trial. In total, 272 participants were randomized 3:1 to a single intravenous dose of 600 mg AZD7442 or placebo and
Jing Zhang, Huixia Zhang, Yajuan Zhang, Shuyuan Liu, Xiaoyun Ge, Haiyue Zhang, Yunfei Li, Cecil Chi‐Keung Chen, Oleg Stepanov, Weifeng Tang, Wenhong Zhang   +10 more
wiley   +1 more source

Interplay of synaptic and backpropagating signals in neurogliaform dendrites

Griesius S, Richardson A, Mercier M, Kullmann DM.   +3 more
europepmc   +1 more source

Safety, Tolerability, and Pharmacokinetics of Galcanezumab, an Anti‐CGRP Antibody, in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Galcanezumab is used in several regions, including the United States, Europe, and China, as a preventive treatment for migraine. This study aimed to evaluate the safety, tolerability, and pharmacokinetics (PK) of galcanezumab in healthy Chinese participants.
Jingjing Wang, Nanyang Li, Jinjie He, Jing Zhang, Lili Wang, William Kielbasa, Chenxi Qian, Yanjie Zhang, Liang Wang   +8 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Bexicaserin in Healthy Participants: A First‐in‐Human Randomized, Double‐Blind, Placebo‐Controlled Single Ascending Dose Escalation Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective 5‐hydroxytryptamine 2C (5‐HT2C) superagonist in development for the treatment of seizures in developmental and epileptic encephalopathies (DEEs). This double‐blind, placebo‐controlled, single ascending dose (SAD) Phase 1 study aimed to assess the safety, tolerability, and pharmacokinetic (PK) and ...
Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R Srinivas, Randall Kaye   +6 more
wiley   +1 more source

Quantifying Mental Stress Using Cardiovascular Responses: A Scoping Review. [PDF]

Sensors (Basel)
Ziyadidegan S, Sadeghi N, Razavi M, Baharlouei E, Janfaza V, Kazeminasab S, Pesarakli H, Javid AH, Sasangohar F.   +8 more
europepmc   +1 more source

A novel adaptive multi-scale wavelet Galerkin method for solving fuzzy hybrid differential equations. [PDF]

Sci Rep
Murugesh V, Priyadharshini M, Sharma YK, Aldossary SM, Kundu S, Malik S, Adem KB, Hashmi A.   +7 more
europepmc   +1 more source

Efficacy of two brands of Mebendazole (500 mg) in the treatment of Ascaris lumbricoides and hookworm infection among school-aged children in South Gondar zone, Northwest Ethiopia: a randomized open label trial. [PDF]

BMC Infect Dis
Malede B, Zeleke AJ, Wondmagegn YM, Setegn A, Wondimu H, Berhan A, Misganaw T, Amare GA, Eshetu T.   +8 more
europepmc   +1 more source

Visuospatial working memory of abacus trained and untrained children. [PDF]

PLoS One
Ansah EE, Nyarko NY, Kumador DK, Owusu-Bempah J, Mahama S.   +4 more
europepmc   +1 more source

Spatiotemporal Assessment of Benzene Exposure Characteristics in a Petrochemical Industrial Area Using Mobile-Extraction Differential Optical Absorption Spectroscopy (Me-DOAS). [PDF]

Toxics
Lee DK, Park JM, Jang JH, Jung JS, Kim MK, Heo J, Park D.   +6 more
europepmc   +1 more source