Results 221 to 230 of about 968,798 (349)

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle   +13 more
wiley   +1 more source

Investigation of a broad‐spectrum micronutrient formulation as a possible precipitant of pharmacokinetic micronutrient–drug interactions

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Daily broad‐spectrum micronutrients are being used by the general public and formulations are receiving research interest in mental health settings. Despite concerns about combining medicines and broad‐spectrum micronutrients in mental health care, there have not been any formal evaluations of potential interactions.
Bess M. Kew   +7 more
wiley   +1 more source

Hardware acceleration of number theoretic transform for zk‐SNARK

open access: yesEngineering Reports, EarlyView., 2023
An FPGA‐based hardware accelerator with a multi‐level pipeline is designed to support the large‐bitwidth and large‐scale NTT tasks in zk‐SNARK. It can be flexibly scaled to different scales of FPGAs and has been equipped in the heterogeneous acceleration system with the help of HLS and OpenCL.
Haixu Zhao   +6 more
wiley   +1 more source

The effect of severe renal impairment on the pharmacokinetics, safety and tolerability of balcinrenone

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this phase 1 trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone (previously AZD9977) in participants with severe renal impairment vs. those with normal renal function. Methods Participants with severe renal impairment (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m2) not on dialysis were ...
Chandrali S. Bhattacharya   +10 more
wiley   +1 more source

The Impact of Calendering Process Variables on the Impedance and Capacity Fade of Lithium‐Ion Cells: An Explainable Machine Learning Approach

open access: yesEnergy Technology, Volume 10, Issue 12, December 2022., 2022
Explainable machine learning in combination with design of experiments and real data is utilized for in‐depth study of the calendering process during Li‐ion battery manufacturing. With focus on the cell's impedance and capacity fade, it is shown that the calendering process control factors such as calendering temperature and gap have different levels ...
Mona Faraji Niri   +4 more
wiley   +1 more source

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