Results 231 to 240 of about 968,798 (349)

Oral paltusotine, a nonpeptide selective somatostatin receptor 2 agonist: Mass balance, absolute bioavailability and metabolism in healthy participants

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paltusotine is a novel, nonpeptide, selective somatostatin receptor 2 agonist in development for the treatment of acromegaly and carcinoid syndrome. This study investigated the mass balance, routes of excretion, absolute bioavailability and metabolite profile of orally administered paltusotine.
Rosa Luo   +6 more
wiley   +1 more source

Numerical Investigation of Compressive Stress and Wettability Effects on Fluid Transport in Polymer Electrolyte Membrane Fuel Cell Porous Layers

open access: yesEnergy Technology, Volume 10, Issue 12, December 2022., 2022
A numerical framework is presented highlighting effects of compressive stress on fluid transport across multiple porous layers in polymer electrolyte membrane fuel cells. Liquid transport characteristics under various compressive conditions are mainly influenced by pore‐scale capillary pressure.
Yanyao Bao, Zhongzheng Wang, Yixiang Gan
wiley   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang   +7 more
wiley   +1 more source

Wearable Wireless Functional Near-Infrared Spectroscopy System for Cognitive Activity Monitoring. [PDF]

open access: yesBiosensors (Basel)
Victorio M   +5 more
europepmc   +1 more source

How school principals' empowering leadership influences teacher autonomy: The mediating role of teachers' academic optimism

open access: yesBritish Educational Research Journal, EarlyView.
Abstract Over the past decade, teacher autonomy has become increasingly significant due to its positive impact on educational outcomes. The study explores the mediating role of teachers' academic optimism in the relationship between school principals' empowering leadership and teacher autonomy.
Hülya Kasapoğlu Tankutay   +1 more
wiley   +1 more source

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