Results 81 to 90 of about 509,522 (270)
Advanced Science, EarlyView.Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi +5 more
wiley +1 more source
Optimal Bounds for Neuman Mean Using Arithmetic and Centroidal Means
Journal of Function Spaces, 2016 We present the best possible parameters α1,α2,β1,β2∈R and α3,β3∈(1/2,1) such that the double inequalities α1A(a,b)+(1-α1)C(a,b)
Ying-Qing Song +2 more
doaj +1 more source
Optimal bounds for two Sándor-type means in terms of power means
Journal of Inequalities and Applications, 2016 In the article, we prove that the double inequalities M α ( a , b ) < S Q A ( a , b ) < M β ( a , b ) $M_{\alpha }(a,b)< S_{QA}(a,b)< M_{\beta}(a,b)$ and M λ ( a , b ) < S A Q ( a , b ) < M μ ( a , b ) $M_{\lambda }(a,b)< S_{AQ}(a,b)< M_{\mu}(a,b)$ hold ...
Tie-Hong Zhao +2 more
doaj +1 more source
Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
Advanced Science, EarlyView.NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
Advanced Science, EarlyView.General schematic of the approach. Abstract Conventional Silver/Silver Chloride (Ag/AgCl) electrodes remain the clinical standard for electrophysiological monitoring but are hindered by poor skin conformity, mechanical rigidity, and signal degradation, particularly under motion or sweat.
Nazmi Alsaafeen +11 more
wiley +1 more source
Operator Arithmetic-Harmonic Mean Inequality on Krein Spaces
Journal of Mathematical Extension, 2014 We prove an operator arithmetic-harmonic mean type inequality in Krein space setting, by using some block matrix techniques of indefinite type. We also give an example which shows that the operator arithmetic-geometric-harmonic mean inequality for two
M. Dehghani, S. M. S. Modarres Mosadegh
doaj
On a result of Cartwright and Field
Journal of Inequalities and Applications, 2018 Let Mn,r=(∑i=1nqixir)1r $M_{n,r}=(\sum_{i=1}^{n}q_{i}x_{i}^{r})^{\frac{1}{r}}$, r≠0 $r\neq 0$, and Mn,0=limr→0Mn,r $M_{n,0}= \lim_{r \rightarrow 0}M_{n,r}$ be the weighted power means of n non-negative numbers xi $x_{i}$, 1≤i≤n $1 \leq i \leq n$, with qi>
Peng Gao
doaj +1 more source
A new class of copulas with tail dependence and a generalized tail dependence estimator [PDF]
We present a new family of copulas (generalized mean copulas) which is positive comprehensive and allows for upper tail dependence. It includes the Spearman copula and a specific Fréchet copula as special cases.
Fischer, Matthias J., Hinzmann, Gerd
core
Advanced Science, EarlyView.This study clarifies the genetic patterns of paternal lineages across East Asia and Mainland Southeast Asia. Han populations are relatively homogeneous, whereas southern ethnolinguistic minorities display regional structures. Shared Y‐chromosome lineages indicate Neolithic expansions and extensive north‐south gene flow, supporting demic diffusion ...
Yunhui Liu +15 more
wiley +1 more source
Advanced Science, EarlyView.A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son +2 more
wiley +1 more source