Results 31 to 40 of about 2,776,980 (290)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Risk Factors and Injury Prevention in the Throwing Athlete

Arthroscopy, Sports Medicine, and Rehabilitation
: Arm injuries are the most common throwing injury, with growing concern as the most severe injuries, such as UCL reconstruction, continue to rise. Furthermore, throwing injuries are frequently recurrent, suggesting once injured, players are at increased
Daniel Kline, P.T., D.P.T, S.C.S., Sarah Kate Fischer, P.T., D.P.T., S.C.S., Garrett S. Bullock, P.T., D.P.T., D.Phil., Michael J. Kissenberth, M.D., Ellen Shanley, P.T., Ph.D., O.C.S., Charles A. Thigpen, P.T., A.T.C., Ph.D.   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Eye Injuries in the U.S. Armed Forces [PDF]

Military Medicine, 2000
To develop prevention and treatment modalities for eye injuries, ophthalmologists require epidemiological data on the various types of eye injuries. This study sought to define eye injury patterns in the U.S. armed forces.Data on patterns of eye injury in the armed forces were obtained through voluntary reporting by U.S.
J J, Lau, A B, Thach, J H, Burden, T P, Ward, P B, Hshieh, R D, Hollifield   +5 more
openaire   +2 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Orthopaedic Injury Patterns Related to Ice Skating, Inline Skating, and Roller Skating: A 20-Year Epidemiologic Analysis

Orthopaedic Journal of Sports Medicine, 2023
Background: Ice skating, inline skating, and roller skating are popular sports in the United States (US). Although they are similar, injuries incurred may be distinct and may have evolved over time.
Meera M. Dhodapkar BA, Scott J. Halperin BS, Elizabeth C. Gardner MD, Jonathan N. Grauer MD   +3 more
doaj   +1 more source

Arthroscopic Lower Trapezius Tendon Transfer for a Patient with Axillary Nerve Injury and Concomitant Rotator Cuff Tear: A Case Report and Technical Notes

Medicina, 2023
Introduction: Concomitant nerve injuries with musculoskeletal injuries present a challenging problem. The goals of nerve reconstruction for the shoulder include shoulder abduction and external rotation.
Jeff Loren, Chuieng-Yi (Johnny) Lu, Cheng-Pang Yang, Kuo-Yao Hsu, You-Hung Cheng, Huan Sheu, Chao-Yu Chen, Hao-Che Tang, Chieh-An Chuang, Chih-Hao (Joe) Chiu   +9 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Trends in incidence and costs of injuries to the shoulder, arm and wrist in The Netherlands between 1986 and 2008

BMC Public Health, 2013
BackgroundUpper extremity injuries account for a large proportion of attendances to the Emergency Department. The aim of this study was to assess population-based trends in the incidence of upper extremity injuries in the Dutch population between 1986 ...
S. Polinder, G. Iordens, M. Panneman, D. Eygendaal, P. Patka, D. den Hartog, E. V. van Lieshout   +6 more
semanticscholar   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source