Results 51 to 60 of about 50,700 (244)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Anthropometric criteria, somatotype and functional performance of basketball players at diff erent stages of sports training

Спортивная медицина: наука и практика, 2020
Objective: to identify the correlation between physical development, somatic physique type, biological maturation and playing positions in basketball. Materials and methods: 112 male basketball players were divided into two groups: group 1 included 75 9 ...
S. V. Matveev, A. K. Uspenskii, Iu. K. Uspenskaia, М. D. Didur   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Using arm span to derive height: Impact of three estimates of height on interpretation of spirometry

Annals of Thoracic Medicine, 2008
Background: When standing height required to calculate forced vital capacity (FVC) cannot be measured, it can be derived from arm span using different methods.
Chhabra S
doaj  

Relationship Between Arm Span Measurements And Body Height In Bijelo Polje [PDF]

Journal of Anthropology of Sport and Physical Education, 2018
In light of rather sparse recent scientific literature, the purpose of this research study was to examine the body height in both sexes of Montenegrin adults nowadays.
Marko Knezevic
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Analysis of Limb segment length to the total body height among the undergraduate students in a medical college of Nepal

Asian Journal of Medical Sciences, 2020
Background: Total body height is important for calculating body mass index, drug dosages calculations and other patient care issues. Total height estimation from different body measurements are surrogate measures of stature which is very useful when only
Muna Kadel, Shanta Hada , Shambhu Nath
doaj   +1 more source

Body Height and Its Assessment By Using the Arm Span of Adolescents From the Montenegrin Municipalities of Berane and Pljevlja [PDF]

Journal of Anthropology of Sport and Physical Education, 2018
The purpose of this research was to examine Montenegrin adolescents’ body height from the municipalities of Berane and Pljevlja, Montenegro. Also, the research examines an arm span as an alternative assessment for measuring the body height which varies
Marija Bubanja
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source