Results 121 to 130 of about 56,011 (338)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Sword of the early sarmatian period from the Ik-Zay interfluve
Поволжская археология, 2015 A sword discovered in 2001 as a stray find in the area of Chaply village (Aznakayevsky District of the Tatarstan Republic) is analyzed in the article. The sword is kept at Aznakayevsky Local History Museum.
Izmaylov Iskander L
doaj
Arming of the U.S. Army During War 1861 [PDF]
, 2019 Grade Level: 9-12 Lesson Length: 60 minutes Learning Objectives: The student will be able to identify the armament of the Union army at the beginning of the Civil War. The student will consider the preparedness of the Union and Confederate armies. The
Colfer, Jessica
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Spartan Daily, March 31, 1960 [PDF]
, 1960 Volume 47, Issue 104https://scholarworks.sjsu.edu/spartandaily/4020/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
, 2014 Excerpt: My initial investigation into Aimee Semple McPherson—founder of The International Church of the Foursquare Gospel—and ecology was bleak: every word search returned a spiritual metaphor. “Garbage” came back as “garbage can of Satan,” “pollution”
Bouma-Prediger, Steven, Swoboda, A.J.
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source