Results 91 to 100 of about 1,848,637 (402)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

War Everywhere: Rights, National Security Law, and the Law of Armed Conflict in the Age of Terror [PDF]

, 2004
Both international and domestic law take as a basic premise the notion that it is possible, important, and usually fairly straightforward to distinguish between war and peace, emergencies and normality, the foreign and the domestic, the external and the ...
Brooks, Rosa Ehrenreich
core   +2 more sources

Organized Armed Groups in a non-International Conflict and International Humanitarian Law

International Review of Law, 2021
Non-International armed conflicts in which different armed groups are involved is the dominant feature of contemporary armed conflicts. Considering the complex and changing alliances of these groups and the extension of their hostilities across borders ...
Eman Hamdan
doaj   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Health perceptions among victims in post-accord Colombia: Focus groups in a province affected by the armed conflict.

PLoS ONE, 2022
The peace agreement with the Colombian guerrilla group Fuerzas Armadas Revolucionarias de Colombia-Ejército del Pueblo represented an opportunity for peacebuilding and victims' reparation, rather than the end of the internal armed conflict.
Catalina González-Uribe, Antonio Olmos-Pinzón, Sebastián León-Giraldo, Oscar Bernal, Rodrigo Moreno-Serra   +4 more
doaj   +1 more source

A geography of illicit crops (coca leaf) and armed conflict in Colombia [PDF]

, 2004
Colombia is currently the world’s largest producer of coca leaf and the principal producer of opium poppies in the Americas; the plants are the basic raw materials used to produce cocaine and heroin.
Díaz, Ana María, Sánchez, Fabio
core  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Mathematical models of intergroup conflicts [PDF]

Compt. rend Acad. sci. Bulg. vol. 61, 993-1002 (2008), 2008
The human society today is far from perfection and conflicts between groups of humans are frequent events. One example for such conflicts are armed intergroup conflicts. The collective behavior of the large number of cooperating participants in these conflicts allows us to describe the conflict on the basis of models containing only few variables.
arxiv  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

The Metamorphosis of the Defense Industry [PDF]

, 2002
The downsizing of the United States defense industry in recent years had a multitude of effects on defense and defense-related manufacturers. Besides the inevitable loss of jobs, these firms essentially had to reinvent themselves in order to compete in ...
Noble, Margaret A.
core   +1 more source