Results 61 to 70 of about 510,131 (357)

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

open access: yesFEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar   +3 more
wiley   +1 more source

Basis of theoretical determination of armed conflict [PDF]

open access: yesВојно дело, 2017
This paper presents the theoretical basis of the origin and development of thoughts of armed conflict. The historical-comparative method, content analysis and the methods of definition and classification have been primarily applied in the paper.
Petrović Ivan   +2 more
doaj   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

open access: yesFEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito   +3 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

open access: yesFEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata   +6 more
wiley   +1 more source

The European Court of Human Rights in a New Reality: Does It Have Sufficient Procedural Infrastructure to Deal with Armed Conflicts? [PDF]

open access: yesJournal of Constitutional Law, 2020
Over the last decades, the European Court of Human Rights had to deal with a large number of individual and interstate cases related to armed conflicts. Despite the fact that its original mandate was not designed for such type of cases, the ECtHR plays a
Giorgi Nakashidze
doaj  

Extracting the Root to Reap the Fruit: Searching for a Possible End to Armed Conflict [PDF]

open access: yes
Putting an end to ideologically motivated armed conflicts in the Philippines does not only entail going to the negotiating table for peace talks but also and more importantly, identifying the possible factors/determinants of the incidence of conflict and
Edillon, Rosemarie G.
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Religious Polarization and the Duration of Civil Wars [PDF]

open access: yes, 2020
More and more research has begun to look at the impact that religion has on armed conflict. This paper takes a closer look at religious polarization and the impact that it has on the duration of civil wars. The central hypothesis focuses on the idea that
Poissant, Adrienne M.
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

COVID-19 and armed conflict

open access: yesWorld Development, 2020
This article studies the impact of COVID-19 on armed conflict. The pandemic has significant health, economic and political effects. These can change the grievances and opportunity structures relevant for armed conflicts to either increase or decrease conflict risks.
openaire   +2 more sources

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