Results 81 to 90 of about 1,848,637 (402)

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Childhood exposure to armed conflict and nutritional health outcomes in Nigeria

Conflict and Health, 2023
Background Armed conflicts are associated with an increased risk of food insecurity, the leading cause of malnutrition in low-and-middle-income countries.
Olusesan Ayodeji Makinde, Emmanuel Olamijuwon, Ifeanyi Mgbachi, Ryoko Sato   +3 more
doaj   +1 more source

Building Peace, Seeking Justice: A Population-Based Survey on Attitudes About Accountability and Social Reconstruction in the Central African Republic [PDF]

, 2010
Analyzes citizens' exposure to violence since 2002 and views on justice, accountability, and conflict resolution. Makes recommendations related to government, armed groups, civil society, the international community, and International Criminal ...
Patrick Vinck, Phuong Pham
core   +1 more source

Conflict-free collective stochastic decision making by orbital angular momentum of photons through quantum interference [PDF]

arXiv, 2021
In recent cross-disciplinary studies involving both optics and computing, single-photon-based decision-making has been demonstrated by utilizing the wave-particle duality of light to solve multi-armed bandit problems. Furthermore, entangled-photon-based decision-making has managed to solve a competitive multi-armed bandit problem in such a way that ...
arxiv  

Political Openness and Armed Conflict: Evidence from Local Councils in Colombia [PDF]

Eur. J. Polit. Econ. 67 (2021) 101984, 2019
In this paper, I empirically investigate how the openness of political institutions to diverse representation can impact conflict-related violence. By exploiting plausibly exogenous variations in the number of councillors in Colombian municipalities, I develop two sets of results.
arxiv   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Access to Justice For Women: India's Response to Sexual Violence in Conflict and Social Upheaval [PDF]

, 2015
A 2014 report by the Special Rapporteur on Violence Against Women on gender-based crimes describes the female experience in India as consisting of a "continuum of violence...from the 'womb to the tomb.'" According to Indian government data, a woman is ...
Angana P. Chatterji, Laurel E. Fletcher, Malika Kaur, Roxanna Altholz   +3 more
core   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Forecasting Change in Conflict Fatalities with Dynamic Elastic Net [PDF]

arXiv, 2022
This article illustrates an approach to forecasting change in conflict fatalities designed to address the complexity of the drivers and processes of armed conflicts. The design of this approach is based on two main choices. First, to account for the specificity of conflict drivers and processes over time and space, we model conflicts in each individual
arxiv