Results 201 to 210 of about 23,637 (262)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

A claim for plant health as a key component of the one health concept. [PDF]

One Health
Albajes R, López MM, Jiménez Díaz RM.
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Rebel responses to disasters in conflict zones: a case study of Cyclone Mocha in Myanmar. [PDF]

Disasters
Kim K.
europepmc   +1 more source

Human Pathogenic Bacteria Within the Nasal and Rectal Microbiome of <i>Macropus giganteus</i>. [PDF]

Trop Med Infect Dis
Arroyo D, Peart A, Vesely B, Trudgian A, Chellappah J.   +4 more
europepmc   +1 more source

"With mental health and land, we have enough to live"-social determinants of mental health in fifteen conflict-affected municipalities of Montes de María, Colombia: a convergent parallel mixed methods study. [PDF]

Confl Health
Rubio-León DC, Cano-Sierra L, Reyes-Rivera MJ, Abitbol P, García-Padilla D, Forero-García SL, López-López W.   +6 more
europepmc   +1 more source

War against superbugs, stopping them before they stop us: a biological warfare approach to safeguard European biosecurity. [PDF]

Trauma Surg Acute Care Open
Uren H, Berrey BH, Gumeniuk K, Kovalchuk V, Moshynets O, Gurney JM, Davis D, Pidvalna U, Beshley D, Godwin Y, Hettiaratchy S, Ressner RA, Ankin ML, Voitsekhovska S, Butler F, Holcomb JB.   +15 more
europepmc   +1 more source

Phage-Based Approaches to Chronic <i>Pseudomonas aeruginosa</i> Lung Infection in Cystic Fibrosis. [PDF]

Antibiotics (Basel)
Hwang W, Yong JH, Lenneman BR, Yonker LM.   +3 more
europepmc   +1 more source

Armed Phages: A New Weapon in the Battle Against Antimicrobial Resistance. [PDF]

Viruses
Anastassopoulou C, Tsakri D, Panagiotopoulos AP, Saldari C, Sagona AP, Tsakris A.   +5 more
europepmc   +1 more source

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The Ritual of Black Armed Resistance

2022
Abstract This chapter looks at police abolition through the perspective of the Black Radical Tradition. It frames the Black Radical Tradition as both an intergenerational birthright and a spiritual inheritance. The transitional moment from childhood that the chapter recounts is, quite explicitly, a rejection of the ideology (and myth ...
exaly   +2 more sources