Results 71 to 80 of about 149,343 (307)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Decorated Great Siege armours for the Hospitaller Knights at the Palace Armoury Museum, Valletta [PDF]
, 2012 The collection of arms and Armour at the Palace Armoury Museum in Valletta represents the Hospitallers' military adaptations during the path of warfare in history and their artistic tastes.
Navarro, Franco
core
Monte Carlo Simulation of the Semimetal-Insulator Phase Transition in Monolayer Graphene [PDF]
, 2009 A 2+1 dimensional fermion field theory is proposed as a model for the low-energy electronic excitations in monolayer graphene. The model consists of N=2 four-component Dirac fermions moving in the plane and interacting via a contact interaction between ...
Armour, Wes +2 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Scrooge\u27s Humbug Dissected [PDF]
, 1990 To Richard Armour (d. 1989), humorist par excellence Scrooge thinks to himself as a man singularly lacking in what we readers see as sensitivity and ...
Fleissner, Robert F.
core +1 more source
The efficiency of ultra-high molecular weight polyethylene composite against fragment impact [PDF]
, 2016 This paper presents an experimental investigation into the ballistic resistance of ultra-high molecular weight polyethylene (UHMW-PE) composite, and compares its performance against a range of common metallic and composite armour materials.
Cimpoeru, S +4 more
core +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Canadian Armour in Normandy: Operation “Totalize” and the Quest for Operational Manoeuvre [PDF]
, 2012 The Allied record in Normandy is irritating simply because we could have done better. The extensive casualty rates to infantry and armour nearly exhausted American arms and created a political crisis in Canada.
Jarymowycz, Roman Johann
core +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source