Results 81 to 90 of about 16,324,159 (410)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Behavioral Arms Control and East Asia

Journal for Peace and Nuclear Disarmament
Growing political and military tensions between China and the United States make it necessary to think of novel arms control approaches on nuclear weapons and certain emerging technologies, designed to include China and other actors.
Ulrich Kühn, Heather Williams
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Occupational health and safety regulations in China: development process, enforcement challenges, and solutions

Frontiers in Public Health
BackgroundOccupational health is closely related to China’s public health system and the construction of a healthy China. The purpose of this paper is to summarize the current health status of China’s occupational population and the dilemmas faced by ...
Xinyu Xu, Xinyu Xu, Xinyu Xu, Peihua Ren, Peihua Ren, Wenyan Shi, Wenyan Shi, Feidan Deng, Feidan Deng, Qingfeng Wang, Qingfeng Wang, Shaoteng Shi, Shaoteng Shi, Jingchun Shen, Jingchun Shen, Guoqiang Dong, Jing Han, Jing Han, Jing Han, Jing Han   +19 more
doaj   +1 more source

On the Whittle Index for Restless Multi-armed Hidden Markov Bandits [PDF]

arXiv, 2016
We consider a restless multi-armed bandit in which each arm can be in one of two states. When an arm is sampled, the state of the arm is not available to the sampler. Instead, a binary signal with a known randomness that depends on the state of the arm is available. No signal is available if the arm is not sampled.
arxiv  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Using Electronic Health Records to Derive Control Arms for Early Phase Single‐Arm Lung Cancer Trials: Proof‐of‐Concept in Randomized Controlled Trials

Clinical pharmacology and therapy, 2019
Oncology drug development increasingly relies on single‐arm clinical trials. External controls (ECs) derived from electronic health record (EHR) databases may provide additional context.
G. Carrigan, S. Whipple, W. Capra, Michael D. Taylor, Jeffrey S. Brown, Michael Lu, B. Arnieri, Ryan Copping, K. Rothman   +8 more
semanticscholar   +1 more source

Open Arms: Open-Source Arms, Hands & Control

, 2022
Open Arms is a novel open-source platform of realistic human-like robotic hands and arms hardware with 28 Degree-of-Freedom (DoF), designed to extend the capabilities and accessibility of humanoid robotic grasping and manipulation.
Hanson, David, Imran, Alishba, Krisciunas, Vytas, Malali, Aman, Mohbe, Rushali, Morales, Gerardo, Sagi, Aditya, Upadrashta, Raviteja   +7 more
core  

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source