Results 201 to 210 of about 984,623 (303)

Paediatric Therapeutic Development Workshop on rhabdomyosarcoma. [PDF]

Br J Cancer
Baxter JS, Montiel Equihua C, Molenaar JJ, Aye J, Bisogno G, Blanc P, Breunis W, Chisholm J, Crane J, Daems S, Danielson L, de Wilde B, Durbin AD, Galvez-Cancino F, Gasparini P, Geoerger B, Graham S, Hassan B, Hatley ME, Heenen D, Heske CM, Hettmer S, Hookham E, Houghton P, Kearns P, Keller C, Khan J, Kinnis F, Langenau D, Lass G, Linardic CM, Mascarenhas L, Meister MT, Metts J, Minard-Colin V, Oberoi S, Palacios D, Pannucci A, Patel S, Patel S, Pomella S, Rabbitts T, Rota R, Rudzinski E, Schäfer B, Shern JJ, Straathof K, Venkatramani R, Wachtel M, Wakeling S, Walters Z, Warburton S, Weigel B, Pearson ADJ, Jenkinson D, Shipley J, Casanova M, LifeArc, Innovative Therapies for Children with Cancer (ITCC), Cancer Research UK, Cancer Grand Challenge PROTECT team.   +60 more
europepmc   +1 more source

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

Molecular and cellular composition changes after neoadjuvant letrozole and palbociclib in early luminal breast cancer. [PDF]

Cell Rep Med
Cottu P, Kieffer Y, Lemonnier J, D'hondt V, Duhoux FP, Callens C, Gentien D, Reyes C, Boulai A, Desmoulins I, Mouret-Reynier MA, Levy C, Heudel PE, Dalenc F, Grenier J, Fuhrmann L, Baulande S, Delaloge S, Mechta-Grigoriou F, Vincent-Salomon A.   +19 more
europepmc   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Adhesion-Related Macrophages Regulate Metabolic Homeostasis Through CAV-1 Dependency. [PDF]

Adv Sci (Weinh)
Hu W, Liao X, Xie L, Sun X, Jing L, Zeng Q, Jiang H, Zhang H, Li L, Wang F, Wang D, Mei Y, Din Y, Song J, Aini W, Zhou H, Xie W, Dai H, Liu W, Liu J, Cheng Y, Liu F, Hsueh WA, Deng T.   +23 more
europepmc   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source

Familial Angiolipomatosis: A Report of Two Cases and Review of Clinicopathologic Features, Diagnostic Considerations, and Management Challenges in an Underserved Population. [PDF]

Cureus
Kandula A, Rana T, Bown P, Diks J.
europepmc   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

The Dual Face of Gingival Mesenchymal Stem Cell Paracrine Signalling in Oral Squamous Cell Carcinoma: A Pro-Tumour Transcriptional Programme and a Hypothesis-Generating Drug-Repurposing Screen. [PDF]

Cells
Alqarni A, Hosmani J, Arem S, Almubarak H, Assiri HA, Meer RM, Patil S.   +6 more
europepmc   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source